New synthetic methods for the chemistry/biology interface

Team Composition

Laurent Micouin, DR

Permanent Staff

E. Benedetti, CRCN, HDR
R. Piccardi, CRCN
S. Turcaud, IR

 

PhD Students

Brom Jules
Simon Felder
Claire Fleurisson
Tuan Zhao
Shiqui Wu

The interests of the group span a wide range of topics in the fields of synthetic organic chemistry and chemical biology, all of them being grounded on molecular innovation. Our works involve the exploration of new chemical spaces as well as the development of synthetic tools or analytical methods for studying and / or interfering with biological regulatory mechanisms. Our research activities are organized around two main axes:

RNA ligands: chemical spaces, probes and analytical methods

Main publications

(click here for all publications)

1. M.-L. Delcourt, S. Felder, E. Benedetti, L. Micouin Highly Enantioselective Desymmetrization of Centrosymmetric pseudo-para-Diformyl [2.2 ]paracyclophane via Asymmetric Transfer Hydrogenation. ACS Catalysis 2018, 8, 6612-6616
2. H. Guyon, F. Mavré, M. Catala, S. Turcaud, F. Brachet, B. Limoges, C. Tisné, L. Micouin Use of a redox probe for an electrochemical RNA–ligand binding assay in microliter droplets Chem. Commun., 2017, 53, 1140-1143
3. M.-L Delcourt, C. Reynaud, S. Turcaud, L. Favereau, J. Crassous, L. Micouin, E. Benedetti 3D Coumarin Systems Based on [2.2]Paracyclophane: Synthesis, Spectroscopic Characterization, and Chiroptical Properties J. Org. Chem. 2019, 84, 888-899
4. P. Gordillo, P. Clerici, L. Micouin Modular Access to N-subtituted cis 5-amino-3-hydroxypiperidines J. Org. Chem. 2017, 82, 7689-7694
5. T. Zhao, R. Piccardi, L. Micouin Rapid and Effective Synthesis of α-Acyloxy-α-alkynyl-trimethylsilanes Organic Lett. 2018, 20, 5015-5018
6. R. Piccardi, S. Turcaud, E. Benedetti, L. Micouin Synthesis and Reactivity of Mixed Dimethylalkynylaluminum Reagents. Synthesis 2019, 51, 97-106

New synthetic methods for the chemistry/biology interface

Team composition

PhD Students

Jules Brom
Simon Felder
Claire Fleurisson
Tuan Zhao
Shiqui Wu

Team Description

The interests of the group span a wide range of topics in the fields of synthetic organic chemistry and chemical biology, all of them being grounded on molecular innovation. Our works involve the exploration of new chemical spaces as well as the development of synthetic tools or analytical methods for studying and / or interfering with biological regulatory mechanisms. Our research activities are organized around two main axes:

RNA ligands: chemical spaces, probes and analytical methods

Main publications

(click here for all publications)

1. M.-L. Delcourt, S. Felder, E. Benedetti, L. Micouin Highly Enantioselective Desymmetrization of Centrosymmetric pseudo-para-Diformyl [2.2 ]paracyclophane via Asymmetric Transfer Hydrogenation. ACS Catalysis 2018, 8, 6612-6616
2. H. Guyon, F. Mavré, M. Catala, S. Turcaud, F. Brachet, B. Limoges, C. Tisné, L. Micouin Use of a redox probe for an electrochemical RNA–ligand binding assay in microliter droplets Chem. Commun., 2017, 53, 1140-1143
3. M.-L Delcourt, C. Reynaud, S. Turcaud, L. Favereau, J. Crassous, L. Micouin, E. Benedetti 3D Coumarin Systems Based on [2.2]Paracyclophane: Synthesis, Spectroscopic Characterization, and Chiroptical Properties J. Org. Chem. 2019, 84, 888-899
4. P. Gordillo, P. Clerici, L. Micouin Modular Access to N-subtituted cis 5-amino-3-hydroxypiperidines J. Org. Chem. 2017, 82, 7689-7694
5. T. Zhao, R. Piccardi, L. Micouin Rapid and Effective Synthesis of α-Acyloxy-α-alkynyl-trimethylsilanes Organic Lett. 2018, 20, 5015-5018
6. R. Piccardi, S. Turcaud, E. Benedetti, L. Micouin Synthesis and Reactivity of Mixed Dimethylalkynylaluminum Reagents. Synthesis 2019, 51, 97-106