New synthetic methods for the chemistry/biology interface
Team Composition
Permanent Staff
E. Benedetti, CRCN, HDR
R. Piccardi, CRCN
S. Turcaud, IR
PhD Students
Brom Jules
Claire Fleurisson
The interests of the group span a wide range of topics in the fields of synthetic organic chemistry and chemical biology, all of them being grounded on molecular innovation. Our works involve the exploration of new chemical spaces as well as the development of synthetic tools or analytical methods for studying and / or interfering with biological regulatory mechanisms. Our research activities are organized around two main axes:
RNA ligands: chemical spaces, probes and analytical methods
Main publications
1. M.-L. Delcourt, S. Felder, E. Benedetti, L. Micouin Highly Enantioselective Desymmetrization of Centrosymmetric pseudo-para-Diformyl [2.2 ]paracyclophane via Asymmetric Transfer Hydrogenation. ACS Catalysis 2018, 8, 6612-6616
2. H. Guyon, F. Mavré, M. Catala, S. Turcaud, F. Brachet, B. Limoges, C. Tisné, L. Micouin Use of a redox probe for an electrochemical RNA–ligand binding assay in microliter droplets Chem. Commun., 2017, 53, 1140-1143
3. M.-L Delcourt, C. Reynaud, S. Turcaud, L. Favereau, J. Crassous, L. Micouin, E. Benedetti 3D Coumarin Systems Based on [2.2]Paracyclophane: Synthesis, Spectroscopic Characterization, and Chiroptical Properties J. Org. Chem. 2019, 84, 888-899
4. P. Gordillo, P. Clerici, L. Micouin Modular Access to N-subtituted cis 5-amino-3-hydroxypiperidines J. Org. Chem. 2017, 82, 7689-7694
5. T. Zhao, R. Piccardi, L. Micouin Rapid and Effective Synthesis of α-Acyloxy-α-alkynyl-trimethylsilanes Organic Lett. 2018, 20, 5015-5018
6. R. Piccardi, S. Turcaud, E. Benedetti, L. Micouin Synthesis and Reactivity of Mixed Dimethylalkynylaluminum Reagents. Synthesis 2019, 51, 97-106
New synthetic methods for the chemistry/biology interface
Team composition
PhD Students
Jules Brom
Simon Felder
Claire Fleurisson
Shiqui Wu
Post-doc
Martin Olivier
Team Description
The interests of the group span a wide range of topics in the fields of synthetic organic chemistry and chemical biology, all of them being grounded on molecular innovation. Our works involve the exploration of new chemical spaces as well as the development of synthetic tools or analytical methods for studying and / or interfering with biological regulatory mechanisms. Our research activities are organized around two main axes:
RNA ligands: chemical spaces, probes and analytical methods
Main publications
1. M.-L. Delcourt, S. Felder, E. Benedetti, L. Micouin Highly Enantioselective Desymmetrization of Centrosymmetric pseudo-para-Diformyl [2.2 ]paracyclophane via Asymmetric Transfer Hydrogenation. ACS Catalysis 2018, 8, 6612-6616
2. H. Guyon, F. Mavré, M. Catala, S. Turcaud, F. Brachet, B. Limoges, C. Tisné, L. Micouin Use of a redox probe for an electrochemical RNA–ligand binding assay in microliter droplets Chem. Commun., 2017, 53, 1140-1143
3. M.-L Delcourt, C. Reynaud, S. Turcaud, L. Favereau, J. Crassous, L. Micouin, E. Benedetti 3D Coumarin Systems Based on [2.2]Paracyclophane: Synthesis, Spectroscopic Characterization, and Chiroptical Properties J. Org. Chem. 2019, 84, 888-899
4. P. Gordillo, P. Clerici, L. Micouin Modular Access to N-subtituted cis 5-amino-3-hydroxypiperidines J. Org. Chem. 2017, 82, 7689-7694
5. T. Zhao, R. Piccardi, L. Micouin Rapid and Effective Synthesis of α-Acyloxy-α-alkynyl-trimethylsilanes Organic Lett. 2018, 20, 5015-5018
6. R. Piccardi, S. Turcaud, E. Benedetti, L. Micouin Synthesis and Reactivity of Mixed Dimethylalkynylaluminum Reagents. Synthesis 2019, 51, 97-106