Nano Bio-Spectroscopy

Team Composition

C. Mangeney, Pr

Permanent Staff

P. Nizard, IR
D. Onidas, MCU, HDR
Y. Sun, CR

 

PhD Students

I. Kerbouche
Y. Xiao

 

The research activity of the Nano Bio-Spectroscopy group is at the interface of nanoscience, spectroscopy, and biomedicine. It focuses on the design of nanoscale tools acting as ideal interfaces to probe biological systems, at different scales. It relies on the elaboration of hybrid nanomaterials and their integration into theranostic agents or advanced “all optical” sensing devices for biological-related applications.

Research activities can be divided into two main topics:

Design of innovative nanoscale hybrid materials

Functional nanoscale hybrid materials are emerging as one of the most promising and rapidly expanding fields in materials chemistry. Our objective is to develop state-of-the-art technologies that will enable the elaboration of innovative hybrid nanomaterials for nanomedecine. We concentrate on the functionalization of plasmonic and magnetic nanoparticles using combination of aryl diazonium salt chemistry and controlled radical polymerization. Key experiments include plasmon-mediated strategies to achieve region-selective and multifunctional surface chemistry, in collaboration with ITODYS Laboratory (Univ. Paris Diderot).

Advanced nanotechnology for drug delivery, diagnostic and theranostic

In recent years, interdisciplinary research on nanomedicine formulations, disease diagnosis and treatment has attracted much international attention as it offers unprecedented opportunities for personalized medicine. We develop in the group an integrated strategy, from the design of innovative multifunctional nanoparticles to the study of their properties and their use as therapeutic, prognosis or diagnostic tools, using Surface-Enhanced Raman scattering (SERS). We also develop nanoscale contrast agents for various optical imaging techniques, such as Raman and photoacoustic imaging, in order to enhance contrast in the NIR region, where tissue optical absorption is minimized. We provide them “smart” features, using thermo- or pH-responsive coatings, in collaboration with MSC Lab (Univ. Paris Diderot).

Team composition

PhD Students

I. Kerbouche
Y. Xiao

Team Description

The research activity of the Nano Bio-Spectroscopy group is at the interface of nanoscience, spectroscopy, and biomedicine. It focuses on the design of nanoscale tools acting as ideal interfaces to probe biological systems, at different scales. It relies on the elaboration of hybrid nanomaterials and their integration into theranostic agents or advanced “all optical” sensing devices for biological-related applications.

Research activities can be divided into two main topics:

Design of innovative nanoscale hybrid materials

Functional nanoscale hybrid materials are emerging as one of the most promising and rapidly expanding fields in materials chemistry. Our objective is to develop state-of-the-art technologies that will enable the elaboration of innovative hybrid nanomaterials for nanomedecine. We concentrate on the functionalization of plasmonic and magnetic nanoparticles using combination of aryl diazonium salt chemistry and controlled radical polymerization. Key experiments include plasmon-mediated strategies to achieve region-selective and multifunctional surface chemistry, in collaboration with ITODYS Laboratory (Univ. Paris Diderot).

Advanced nanotechnology for drug delivery, diagnostic and theranostic

In recent years, interdisciplinary research on nanomedicine formulations, disease diagnosis and treatment has attracted much international attention as it offers unprecedented opportunities for personalized medicine. We develop in the group an integrated strategy, from the design of innovative multifunctional nanoparticles to the study of their properties and their use as therapeutic, prognosis or diagnostic tools, using Surface-Enhanced Raman scattering (SERS). We also develop nanoscale contrast agents for various optical imaging techniques, such as Raman and photoacoustic imaging, in order to enhance contrast in the NIR region, where tissue optical absorption is minimized. We provide them “smart” features, using thermo- or pH-responsive coatings, in collaboration with MSC Lab (Univ. Paris Diderot).

Main publications

1. I. Tijunelyte, I. Kherbouche et al. Multi-functionalization of lithographically designed gold nanodisks by plasmon-mediated reduction of aryl diazonium salts. Nanoscale Horiz. 2018, 3, 53-57
2. S. Gam-Derouich, C. Bourdillon et al. Imprinted photonic hydrogels for the size and shell-selective recognition of nanoparticles. Angew. Chem. Int. Ed., 2017, 33, 9710–9714.

3. R. Rebois, D. Onidas, C. Marcott et al. Chloroform induces outstanding crystallization of poly(hydroxybutyrate) (PHB) vesicles within bacteria. Anal. Bioanal., Chem. 2017, 409(9), 2353-2361.
4. M. Nguyen, A. Lamouri, C. Salameh, G. Levi et al. Plasmon-Mediated Chemical Surface Functionalization at the Nanoscale, Nanoscale, 2016, 8, 8633-8640.
5. M. Nguyen, X. Sun, E. Lacaze, P. Winkler et al. Engineering Thermo-switchable Lithographic Hybrid Gold Nanorods for Sensing and Active Plasmonics Applications. ACS Photonics, 2015, 2 (8), 1199–1208.
6. R. Ahmad, N. Griffete, A. Lamouri, N. Félidj et al. Nanocomposites of gold nanoparticles@molecularly imprinted polymers: chemistry, processing and applications in sensors. Chem. Mater, 2015, 27 (16), 5464–5478.