Nano Bio-Spectroscopy

Team Composition

C. Mangeney, Pr

Permanent Staff

P. Nizard, IR
D. Onidas, MCU
Y. Luo, CR

 

PhD Students

Y. Xiao
D. Li
H. Chen (coll. F. Gazeau, Université Paris Cité)
Y. Zhang (Co-dir. Dr. Graciela Pavon-Djavid, Université Sorbonne Paris Nord)

 

Internship Students

K. Pandey
A. Chali

L. Lim

 

The research activity of the Nano Bio-Spectroscopy group is at the interface of nanoscience, spectroscopy, and biomedicine. It focuses on the design of nanoscale tools acting as ideal interfaces to probe biological systems, at different scales. It relies on the elaboration of hybrid nanomaterials and their integration into theranostic agents or advanced “all optical” sensing devices for biological-related applications.

Research activities can be divided into two main topics:

Design of innovative nanoscale hybrid materials

Functional nanoscale hybrid materials are emerging as one of the most promising and rapidly expanding fields in materials chemistry. Our objective is to develop state-of-the-art technologies that will enable the elaboration of innovative hybrid nanomaterials for nanomedecine. We concentrate on the functionalization of plasmonic and magnetic nanoparticles using combination of aryl diazonium salt chemistry and controlled radical polymerization. Key experiments include plasmon-mediated strategies to achieve region-selective and multifunctional surface chemistry, in collaboration with ITODYS Laboratory (Université de Paris).

Advanced nanotechnology for drug delivery, diagnostic and theranostic

In recent years, interdisciplinary research on nanomedicine formulations, disease diagnosis and treatment has attracted much international attention as it offers unprecedented opportunities for personalized medicine. We develop in the group an integrated strategy, from the design of innovative multifunctional nanoparticles to the study of their properties and their use as therapeutic, prognosis or diagnostic tools, using Surface-Enhanced Raman scattering (SERS). We also develop nanoscale contrast agents for various optical imaging techniques, such as Raman and photoacoustic imaging, in order to enhance contrast in the NIR region, where tissue optical absorption is minimized. We provide them “smart” features, using thermo- or pH-responsive coatings, in collaboration with MSC Lab (Université de Paris).

Team composition

 

PhD Students

Y. Xiao
D. Li
H. Chen (coll. F. Gazeau, Université Paris Cité)
Y. Zhang (Co-dir. Dr. Graciela Pavon-Djavid, Université Sorbonne Paris Nord)

Internship Students

K. Pandey
A. Chali

L. Lim

Team Description

The research activity of the Nano Bio-Spectroscopy group is at the interface of nanoscience, spectroscopy, and biomedicine. It focuses on the design of nanoscale tools acting as ideal interfaces to probe biological systems, at different scales. It relies on the elaboration of hybrid nanomaterials and their integration into theranostic agents or advanced “all optical” sensing devices for biological-related applications.

Research activities can be divided into two main topics:

Design of innovative nanoscale hybrid materials

Functional nanoscale hybrid materials are emerging as one of the most promising and rapidly expanding fields in materials chemistry. Our objective is to develop state-of-the-art technologies that will enable the elaboration of innovative hybrid nanomaterials for nanomedecine. We concentrate on the functionalization of plasmonic and magnetic nanoparticles using combination of aryl diazonium salt chemistry and controlled radical polymerization. Key experiments include plasmon-mediated strategies to achieve region-selective and multifunctional surface chemistry, in collaboration with ITODYS Laboratory (Université de Paris).

Advanced nanotechnology for drug delivery, diagnostic and theranostic

In recent years, interdisciplinary research on nanomedicine formulations, disease diagnosis and treatment has attracted much international attention as it offers unprecedented opportunities for personalized medicine. We develop in the group an integrated strategy, from the design of innovative multifunctional nanoparticles to the study of their properties and their use as therapeutic, prognosis or diagnostic tools, using Surface-Enhanced Raman scattering (SERS). We also develop nanoscale contrast agents for various optical imaging techniques, such as Raman and photoacoustic imaging, in order to enhance contrast in the NIR region, where tissue optical absorption is minimized. We provide them “smart” features, using thermo- or pH-responsive coatings, in collaboration with MSC Lab (Université de Paris).

Main publications

1. D. Li, P. Nizard et al. SERS Tags Derived from Silver Nanoparticles and Aryl Diazonium Salts for Cell Raman Imaging. Nanoscale 2022, 14, 1452. https://doi.org/10.1039/D1NR03148A

2. D. Li, Y. Luo et al. Surface functionalization of nanomaterials by aryl diazonium salts for biomedical sciences. Adv. Colloid & Interface Science 2021, 294, 102479. https://doi.org/10.1016/j.cis.2021.102479

3. Y. Xiao, J. Gateau et al. Hybrid nano- and microgels doped with photoacoustic contrast agents for cancer theranostics View 2021, 2:20200176. https://doi.org/10.1002/VIW.20200176

4. A. Barosi, A. Berisha et al. Efficient construction of redox responsive thin polymer layer on carbon and gold for voltage-gated delivery applications Materials Adv. 2021, 2, 2358. https://doi.org/10.1039/D1MA00022E

5. I. Kherbouche, Y. Luo et al. Plasmon-Mediated Surface Functionalization: New Horizons for the Control of Surface Chemistry on the Nanoscale Chem. Mater. 2020, 32, 5442. https://doi.org/10.1021/acs.chemmater.0c00921

6. Y. Luo, Y. Xiao et al. Raman reporters derived from aryl diazonium salts for SERS encoded-nanoparticles Chem. Commun. 2020, 56, 6822. https://doi.org/10.1039/D0CC02842H