New synthetic methods for the chemistry/biology interface

Team Composition

Laurent Micouin, DR

Permanent Staff

Erica. Benedetti, CRCN, HDR
Dylan, Coelho, IR
Anton Granzhan, CRCN, HDR
Riccardo. Piccardi, CRCN

PhD Students

Jiayi Zhu
Brian Deboutière
Camille Richagneux

Post-Doc

Joseph Boissieras
Rongyu Sun

Past Members

Pictures

The interests of the group span a wide range of topics in the fields of synthetic organic chemistry and chemical biology, all of them being grounded on molecular innovation. Our works involve the exploration of new chemical spaces as well as the development of synthetic tools or analytical methods for studying and / or interfering with biological regulatory mechanisms. Our research activities are organized around two main axes:

RNA ligands: chemical spaces, probes and analytical methods

Diversity-oriented-synthesis of cyclic polyamines

Chiral paracyclophanes

RNA/ligand interactions

Organometallic chemistry and molecular diversity: Synthesis and reactivity of organoaluminum reagents

Main publications

(click here for all publications)

1. M.-L. Delcourt, S. Felder, E. Benedetti, L. Micouin Highly Enantioselective Desymmetrization of Centrosymmetric pseudo-para-Diformyl [2.2 ]paracyclophane via Asymmetric Transfer Hydrogenation. ACS Catalysis 2018, 8, 6612-6616

2. H. Guyon, F. Mavré, M. Catala, S. Turcaud, F. Brachet, B. Limoges, C. Tisné, L. Micouin Use of a redox probe for an electrochemical RNA–ligand binding assay in microliter droplets Chem. Commun., 2017, 53, 1140-1143

3. M.-L Delcourt, C. Reynaud, S. Turcaud, L. Favereau, J. Crassous, L. Micouin, E. Benedetti 3D Coumarin Systems Based on [2.2]Paracyclophane: Synthesis, Spectroscopic Characterization, and Chiroptical Properties J. Org. Chem. 2019, 84, 888-899

4. P. Gordillo, P. Clerici, L. Micouin Modular Access to N-subtituted cis 5-amino-3-hydroxypiperidines J. Org. Chem. 2017, 82, 7689-7694

5. T. Zhao, R. Piccardi, L. Micouin Rapid and Effective Synthesis of α-Acyloxy-α-alkynyl-trimethylsilanes Organic Lett. 2018, 20, 5015-5018

6. R. Piccardi, S. Turcaud, E. Benedetti, L. Micouin Synthesis and Reactivity of Mixed Dimethylalkynylaluminum Reagents. Synthesis 2019, 51, 97-106