Research Scientist, CNRS

Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques (LCBPT) – CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06

Laboratoire de Chimie et Biochimie
Pharmacologiques et Toxicologiques (LCBPT)
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06

Curriculum Vitae

Academic and Professional Background :

2015- Health and safety assistant
2014-  CNRS Researcher. UMR 8601, University of Paris Descartes.
2009- 2014  CNRS Researcher. UMR 8182, University of Paris Sud.
2008-2009 Temporary Associate Professor (ATER). UMR 8182, University of Paris Sud.
2006-2008 Post-Doctoral Fellow University of Claude Bernard Lyon I (with Prof. O. Baudoin)
2005-2006 Post-Doctoral Fellow Technical University of Munich (TUM)-Germany (with Prof. T. Bach)
2001-2005 Ph.D. in chemistry. University of Bern-Switzerland (with Prof. P. Renaud)
20002001 Master in Chemistry (Laurea). University of Florence -Italy (with Dr. G. Reginato)


Research Interest

Study of the synthesis and reactivity of organoaluminum reagents, in particular of dimethylalkynylaluminum reagents.
Study of the reactivity if silylated diazoalkynes
Flow chemistry applied to organometallic compounds and in particular to aluminum derivatives.


  1. T. Zhao, E. Sachon, L. Micouin, R. Piccardi α-Silylated Diazoalkynes: New Tools for Bioconjugation of Proteins” 2024, just accepted.
    DOI: 10.1002/chem.202302807
  1. Zhao, L. Micouin, R. Piccardi. “Synthesis of Organometallic Compounds in Flow”. Helv. Chim. Acta, 2019⟨10.1002/hlca.201900172⟩.
  1. Piccardi, S. Turcaud, E. Benedetti, L. Micouin. “Synthesis and Reactivity of Mixed Dimethylalkynylaluminum Reagents”. Synthesis, 2018, 51, 97-106. ⟨10.1055/s-0037-1610392⟩.
  2. Zhao, R. Piccardi, L. Micouin. “Rapid and Effective Synthesis of α-Acyloxy-α-alkynyltrimethylsilanes”. Org. Lett. 2018, 20, 5015-5018. ⟨10.1021/acs.orglett.8b02165⟩.
  1. R. Piccardi, A. Coffinet, E. Benedetti, S. Turcaud, L. Micouin, “Continuous flow synthesis of dimethylalkynylaluminum reagents” Synthesis 2016, 48, 3272-3278
  2. R. Piccardi, L. Micouin, O. Jackowski “The Chemistry of Alkynylaluminum Species”. I. Marek Ed. PATAI’S Chemistry of Functional Groups, John Wiley & Sons, Ltd, 1-47, 2016, DOI: https://doi.org/10.1002/9780470682531.pat0832
Older publications
  1. Prosa, R. Turgis, R. Piccardi, M.-C. Scherrmann, “Soluble Polymer-Supported Flow Synthesis: A Green Process for the Preparation of Heterocycles” Eur. J. Org. Chem. 2012, 2188-2200
  2. Chaumontet, R. Piccardi, O. BaudoinSynthesis of 3,4-Dihydroisoquinolines by a C(sp3)–H Activation-Electrocyclization Strategy: Total Synthesis of Coralydine” Angew. Chem. Int. Ed. 2009, 48, 179-182
  3. Chaumontet, R. Piccardi, N. Audic, J. Hitce, J.-L. Peglion, E. Clot, O. Baudoin, “Synthesis of Benzocyclobutenes by Palladium-Catalyzed C−H Activation of Methyl Groups: Method and Mechanistic Study” J. Am. Chem. Soc. 2008, 130, 15157 – 15166 
  4. Piccardi, P. Renaud, “Formal Synthesis of (+) and (-)-Ferruginine” Eur. J. Org. Chem. 2007, 10, 4752-4757.
  5. Reginato, A. Mordini, M. Valacchi, R. PiccardiSynthesis of non-racemic b-branched a-(aminoalkyl)-acrylates from naturally occurring amino acids” Tetrahedron: Asymmetry 2002, 13, 595-600