Chemistry towards life sciences,
Macromolecular Modeling Platform

+33 1 76 53 42 37, room R150

Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques (LCBPT) – CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Curriculum Vitae

2012: PhD in organic chemistry

University of Paris Descartes, team « Organic synthesis for biomedical research, group of Pr. Y. Le Merrer

Sept.2002-… : R&D Engineer recruitment, CNRS

University of Paris Descartes, Laboratoire de Chimie et Biochimie Pharmacologique et Toxicologique

Sept.1998-sept.2002: R&D Engineer

University of Perpignan, Laboratoire des Produits Naturels et de Chimie Environnementale

Jan. 1998-sept. 1998: R&D Engineer

University of Lausanne, Institut de chimie organique, group of Pr. M. Schlosser.

1996: MSc in Fine Organic Chemistry, ENSCM

Publications

1. Le Corre, L.; Padovani, D. “Mechanism‑based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition.” Scientific Reports 2023, 13:7287. https://doi.org/10.1038/s41598-023-34405-3
2. Nouri, K.; Pietrancosta, N.; Le Corre, L.; Dansette, P.M.; Mansuy,D.; Boucher, J.-L. “Human Orphan Cytochrome P450 2U1 Catalyzes the ω-Hydroxylation of Leukotriene B4.”  Int. J. Mol. Sci. 2022, 23, 14615. https://doi.org/10.3390/ijms232314615
3. Oliver, M.; Le Corre, L.; Poinsot, M.; Bosco, M.; Wan, H.; Amoroso, A.; Joris, B.; Bouhss, A.; Calvet-Vitale, S.; Gravier-Pelletier, C.;  “A Sub-Micromolar MraYAA Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling.” Molecules 2022, 27(6),  1769.  https://doi.org/10.3390/molecules2706176
4. Pujol C, Legrand A, Parodi L, Boucher, J.-L.; Le Corre, L. et al. “Implication of folate deficiency in CYP2U1 loss of function.” J Exp Med. 2021; 218(11):e20210846. https://doi.org/10.1084/jem.20210846
5. Oliver, M.; Le Corre, L.; Poinsot, M.; Bosco, M.; Wan, H.; Amoroso, A.; Joris, B.; Bouhss, A.; Calvet-Vitale*, S.; Gravier-Pelletier, C. “A sub-micromolar MraYAA Inhibitor with an aminoribosyl uridine structure and a (S,S)-tartaric diamide: Synthesis, biological evaluation and molecular modeling.” Molecules 2022, 27, 1769. https://doi.org/10.3390/molecules27061769
6. Oliver, M.; Le Corre, L.; Poinsot, M.; Corio, A.; Madegard, L.; Bosco, M.; Amoroso, A.; Joris, B.; Auger, R.; Touzé, T.; Bouhss, A.; Calvet-Vitale, S.; Gravier-Pelletier, C.“Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors.”  Org. Biomol. Chem. 2021, 19 (26), 5844-5866, DOI: 10.1039/D1OB00710F.
7. T. Zhang, L. Le Corre, O. Reinaud, B. Colasson. “A Promising Approach for Controlling the 2nd Coordination Sphere of Biomimetic Metal Complexes: Encapsulation in a Dynamic Hydrogen-Bonded Capsule.”, Chem. Eur. J. 2021, 27, 434-443. DOI:/10.1002/chem.202004370
8. Ashraf, U.; Tengo, L.; Le Corre, L.; Fournier, G.; Busca, P.; McCarthy, A. A.; Rameix-Welti, M.-A.; Gravier-Pelletier, C.; Ruigrok, R. W. H.; Jacob, Y.; et al. Destabilization of the Human RED-SMU1 Splicing Complex as a Basis for Host-Directed Antiinfluenza Strategy.”  Natl. Acad. Sci. U. S. A. 2019,116(22), 10968–10977. https://doi.org/10.1073/pnas.1901214116.
9. Morlot, C.; Straume, D.; Peters, K.; Hegnar, O. A.; Simon, N.; Villard, A.-M.; Contreras-Martel, C.; Leisico, F.; Breukink, E.; Gravier-Pelletier, C.; et al. Structure of the Essential Peptidoglycan Amidotransferase MurT/GatD Complex from Streptococcus Pneumoniae.  Commun.2018, 9. https://doi.org/10.1038/s41467-018-05602-w.
10. Fer, M. J.; Le Corre, L.; Pietrancosta, N.; Evrard-Todeschi, N.; Olatunji, S.; Bouhss, A.; Calvet-Vitale, S.; Gravier-Pelletier, C. Bacterial Transferase MraY, a Source of Inspiration towards New Antibiotics.  Med. Chem.2018, 25 (42), 6013–6029. https://doi.org/10.2174/0929867325666180330095154.