Julien DAIROU

Assistant Professor
Biological chemistry

+33 1 76 53 42 35, room R142

Laboratoire de Chimie et Biochimie
Pharmacologiques et Toxicologiques (LCBPT)
CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Julien DAIROU

Assisatnt Professor

Biological chemistry


+33 1 76 53 42 35, room R142

Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques (LCBPT) – CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Curriculum Vitae

Education

2010: Accreditation to direct research in Toxicology (HDR)

2003: PhD thesis in Molecular Biophysics

1999: Master degree in Molecular Biophysics

Summary

Biochemist and Biophysicist, researcher since 2003 in metabolic and toxicological enzymology, I was hired in 2006 as a lecturer at the University Paris Diderot (CNRS UMR8251). Since 2015, I joined the laboratory of Chemistry and Biochemistry (LCPBT, University Paris Descartes/CNRS UMR8601). Researcher passionate about metabolism and his means of investigation (analytical chemistry) Organized, demanding, rigorous with a sense of responsibility and ethics, stimulated by teamwork and collaborative projects. With a particular talent for the development of methods of analysis.

  • Research (Analytical chemistry, metabolism, toxicology)
  • Teaching (Biochemistry and Analytical Chemistry Levels License, Master and PhD)

Experiences

Paris University Associate professor                                                                              2006 – Present

  • Creation and development of Bioprofiler (2009 – 2014) and management of Mass Spectrometry facilities of UMR8601 (2017-present), an analytical chemistry facility dedicated to qualitative and quantitative analyzes of biomolecules and xenobiotics (physiological markers, pharmacological and toxicological analyzes).
  • Grants, Bioprofiler (Budget of 500 k€), familiar with government procurement orders and supplier relationships.
  • Management of research programs on Bioprofiler (Evaluation and valorization of scientific projects and industrial contracts). Collaboration over 20 academic laboratories (international and national) and several industrial partners. Participation and/or direction of several research programs (budget between 20 k€ to 350 k€; ANR, ANSES, European project Alliance)
  • Team management: training of four engineers. Direction of the research work of a dozen PhD students and Master students.
  • Director of B2IP training of the Bachelor of Life Sciences of the university (150 students).

CNRS UMR7000: Post-doctorant fellow                                                                   2005-2006

  • 2-year internship at the CNRS UMR7000: Identification and study of the oxidative regulation of enzymes expressed in the muscle.

Université Paris Diderot: Enseignant-Chercheur postdoctorant                   2003-2004

  • 2-year internship at the biochemistry department of Paris Diderot University: Study of the redox regulation of an enzyme of xenobiotic metabolism.

Scientific activities and communications

  • Peer reviews publications:
  • 86 publications in international peer-reviewed journals of which 65% in first / second or last position (h index = 20).
  • 2 chapters of books.
  • 1 patent (246859 / D31573: 3,5-diaryl-azaindoles as inhibitors of the protein Dyrk1a for the treatment of cognitive impairments related to Down syndrome and Alzheimer’s disease).
  • More than 60 oral and poster presentations at international and national conferences.
  • Organization of two congresses (Member of the organizing committee of the 5th International Workshop on Arylamine N-acetyltransferases (2010) and the 2013 congress of the French Society of Biochemistry and Molecular Biology (SFBBM) «Enzymes: Structure / Function / Catalysis / Engineering / Regulation »
  • International and national expertise
  • Reviews for international publications
  • Reviewer and participation in 6 thesis juries.
  • Invited research sessions in the Department of Pharmacology at Oxford University by Professor E Sim (2003, 2008 and 2010).
  • Member of the Life Sciences Platform Committee of Paris Rive Gauche Paris Diderot (2009-2014)
  • Expert reports for private partners
  • Member of selection committees for the recruitment of senior lecturers (2009, 2011 and 2015).

Skills

  • Biochemistry: Advanced Mastery of Common Concepts and Practices in Molecular Biology and Biochemistry of Proteins:
    • DNA extraction / purification, PCR, subcloning, fusion protein construction, site-directed mutagenesis.
    • Extraction and purification of proteins in E. coli and yeast (immunoprecipitation, SDS-PAGE, Western blot).
    • Enzymology (Determination of the kinetic parameters of an enzyme, enzymatic assays for the quantification of xenobiotics)
    • Immunological assays (ELISA, EMIT, CEDIA)
    • Calorimetry (ITC, DSC)
  • Analytical Chemistry:
    • HPLC/UPLC (All types of detections: Absorbance, PDA, Mass Spectrometry, Fluorescence, Electrochemical, light scattering)
    • GC (Masse Spectrometry and FID)
    • Other chromatographies (Flash, TLC, Ionic, Low pressure and Capillary)
  • Toxicology (Good knowledge of xenobiotic metabolism and analytical toxicology: detection, identification and quantification of xenobiotics and their metabolites)
  • Informatics:
    • Programming: Excel macro, HTML
    • Analytical Chemistry and Bioinformatics Software (Xcalibur ™, LabSolutions, Empower ™, ChromQuest ™, Mnova®, ChemDraw® and Pymol)
    • Biological data processing (use of GraphPad Prism, Origin®, SnapGene, Endnote® and Access® online databases).

Publications

  1. Dairou J, Vever-Bizet C, Brault D. “Self-association of disulfonated deuteroporphyrin and its esters in aqueous solution and photosensitized production of singlet oxygen by the dimers” Photochem Photobiol (2002) 75:229-36.
  2. Atmane N, Dairou J, Paul A, Dupret JM, Rodrigues-Lima F. “Redox regulation of the human xenobiotic metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1). Reversible inactivation by hydrogen peroxide” J Biol Chem (2003) 278:35086-92.
  3. Dairou J, Atmane N, Dupret JM, Rodrigues-Lima F. “Reversible inhibition of the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 by S-nitrosothiols” Biochem Biophys Res Commun (2003) 307:1059-65.
  4. Dairou J, Vever-Bizet C, Brault D. “Interaction of sulfonated anionic porphyrins with HIV glycoprotein gp120: photodamages revealed by inhibition of antibody binding to V3 and C5 domains” Antivir Res (2004) 61(1):37-47.
  5. Dairou J, Atmane N, Rodrigues-Lima F, Dupret JM. “Peroxynitrite irreversibly inactivates the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: a cellular and mechanistic study” J Biol Chem (2004) 279(9):7708-14.
  6. Dupret JM, Dairou J, Atmane N, Rodrigues-Lima F. “Pharmacogenetics, Regulation and Structural Properties of the Drug metabolizing Enzymes Arylamine N-acetyltransferases” Current Pharmacogenomics (2004) 2(4), 333-8.
  7. Dairou J, Malecaze F, Dupret JM, Rodrigues-Lima F. “The Xenobiotic-metabolizing Enzymes Arylamine N-acetyltransferases (NAT) in Human Lens Epithelial Cells: Inactivation by Cellular Oxidants and UVB-induced Oxidative Stress” Mol Pharmacol (2005) 67(4):1299-306.
  8. Holton SJ, Dairou J, Sandy J, Rodrigues-Lima F, Dupret JM, M. E. M. Noble and E. Sim “Structure of Mesorhizobium loti arylamine N-acetyltransferase 1” Acta Cryst F (2005) 61, 14-16.
  9. Dupret JM, Dairou J, Atmane N, Rodrigues-Lima F. “Inactivation of human arylamine N-acetyltransferase 1 by hydrogen peroxide and peroxynitrite” Methods Enzymol (2005) 400, 215-29.
  10. Dairou J, Dupret JM, Rodrigues-Lima F. “Impairment of the activity of the xenobiotic-metabolizing enzymes arylamine N-acetyltransferases 1 and 2 (NAT1/NAT2) by peroxynitrite in mouse skeletal muscle cells” FEBS Lett. (2005) 579 (21), 4719-23.
  11. Dairou J, Flatters D, Chaffotte AF, Pluvinage B, Sim E, Dupret JM, Rodrigues-Lima F. “Insight into the structure of Mesorhizobium loti arylamine N-acetyltransferase 2 (MLNAT2): A biochemical and computational study” FEBS Lett. (2006) 580 (7):1780-8.
  12. Rodrigues-Lima F, Dairou J, Diaz CL, Rubio MC, Sim E, Spaink HP, Dupret JM. “Rhizobial symbiosis supplies leguminous plants with the xenobiotic N-acetylation pathway: cloning, functional expression and characterization of Mesorhizobium loti arylamine N-acetyltransferases” Mol Microbiology (2006) 60(2):505-12.
  13. Hamelet J, Demuth K, Dairou J, Ledru A, Paul JL, Dupret JM, Delabar JM, Rodrigues-Lima F, Janel N. “Effects of catechin on homocysteine metabolism in hyperhomocysteinemic mice” Biochem Biophys Res Commun (2007) 355(1):221-7.
  14. Pluvinage B. Dairou J, Possot MO, Martins M, Fouet A, Dupret JM, Rodrigues-lima, F. “Cloning and molecular characterization of three arylamine N-Acetyltransferase genes from Bacillus anthrancis: Identification of unusual enzymatic properties and their contribution to sulfamethoxazole resistance” Biochemistry (2007) 46(23):7069-78.
  15. Dairou J, Pluvinage B, Noiran J, Petit E, Vinh J, Haddad I, Mary J, Dupret JM, Rodrigues-Lima F. “Nitration of a critical tyrosine residue in the allosteric inhibitor site of muscle glycogen phosphorylase impairs its catalytic activity” J Mol Biol (2007) 372(4):1009-21.
  16. Atmane N, Dairou J, Flatters D, Martins M, Pluvinage B, Derreumaux P, Dupret JM, Rodrigues-Lima F. “The conserved glycine/alanine residue of the active-site loop containing the putative acetylCoA-binding motif is essential for the overall structural integrity of Mesorhizobium loti arylamine N-acetyltransferase 1” Biochem Biophys Res Commun (2007) 361(1):256-62.
  17. Ragunathan N, Dairou J, Pluvinage B, Martins M, Petit E, Janel N, Dupret JM, Rodrigues-Lima F. “Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 as a new target of cisplatin in breast cancer cells: molecular and cellular mechanisms of inhibition” Mol Pharmacol (2008) 73(6):1761-8.
  18. Rodrigues-Lima F, Dairou J, Dupret JM. “Effect of environmental substances on the activity of arylamine N-acetyltransferases” Curr Drug Metab (2008) 9(6):505-9.
  19. Martins M, Pluvinage B, de la Sierra-Gallay IL, Barbault F, Dairou J, Dupret JM, Rodrigues-Lima F. “Functional and structural characterization of the arylamine N-acetyltransferase from the opportunistic pathogen Nocardia farcinica” J Mol Biol (2008) 383(3):549-60.
  20. Dairou J, Petit E, Ragunathan N, Baeza-Squiban A, Marano F, Dupret JM, Rodrigues-Lima F. “Arylamine N-acetyltransferase activity in bronchial epithelial cells and its inhibition by cellular oxidants” Toxicol Appl Pharmacol (2009) 236(3):366-71.
  21. Martins M, Rodrigues-Lima F, Dairou J, Lamouri A, Malagnac F, Silar P, Dupret JM. “An acetyltransferase conferring tolerance to toxic aromatic amine chemicals: molecular and functional studies” J Biol Chem (2009) 284(28):18726-33.
  22. Ragunathan N, Dairou J, Pluvinage B, Martins M.; Dupret JM, Rodrigues-Lima F. “Human arylamine N-acetyltransferase 1 (NAT1) as a target of chemotherapeutic drugs in breast cancer: cisplatin as a model.” Mol Cell Pharmacol (2009) 1 (1), 7-10.
  23. Malka F, Dairou J, Ragunathan N, Dupret JM, Rodrigues-Lima F. “Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulfiram” FEBS J. (2009) 276(17):4900-8.
  24. Rodrigues-Lima F, Dairou J, Busi F, Dupret JM “Human Arylamine N-Acetyltransferase 1: A Drug-Metabolizing Enzyme and a Drug Target?” Curr Drug Targets (2010) 11(6):759-66.
  25. Ragunathan N, Busi F, Sanfins E, Dupret JM, Rodrigues-Lima F, Dairou J. “The human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) is irreversibly inhibited by inorganic (Hg2+) and organic mercury (CH3Hg+): Mechanism and kinetics” FEBS Letters (2010) 584(15):3366-9.
  26. Martins M, Dairou J, Rodrigues-Lima F, Dupret JM, Silar P “Insights into the phylogeny or arylamine N-acetyltransferases in fungi.” J Mol Evol. (2010) 71(2):141-52.
  27. Ragunathan N, Dairou J, Sanfins E, Busi F, Noll C, Janel N, Dupret JM, Rodrigues-Lima F. ” Cadmium alters the biotransformation of carcinogenic aromatic amines by arylamine N-acetyltransferase xenobiotic-metabolizing enzymes: molecular, cellular, and in vivo studies.” Environ Health Perspect. (2010); 118(12):1685-91.
  28. Noll C, Raaf L, Planque C, Benard L, Secardin L, Petit E, Dairou J, Paul JL, Samuel JL, Delcayre C, Rodrigues-Lima F, Janel N. “Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice.” J Nutr Biochem. (2011), 22(9):856-64.
  29. Silar P, Dairou J, Cocaign A, Busi F, Rodrigues-Lima F, Dupret JM. “Fungi as a promising tool for bioremediation of soils contaminated with aromatic amines, a major class of pollutants“ Nat Rev Microbiol. (2011) 9(6):477.
  30. Sanfins E, Dairou J, Rodrigues-Lima F, Dupret J M. “Nanoparticle-protein interactions: from crucial plasma proteins to key enzymes” J Phys Conf Ser (2011) 304.
  31. Sanfins E, Dairou J, Hussain S, Busi F, Chaffotte AF, Rodrigues-Lima F, Dupret JM. “Carbon black nanoparticles impair acetylation of aromatic amine carcinogens through inactivation of arylamine N-acetyltransferase enzymes.” ACS Nano. (2011) 28;5(6):4504-11
  32. Noll C, Dairou J, Ripoll C, Paul JL, Dupret JM, Delabar JM, Rodrigues-Lima F, Janel N. “Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice.” Food Chem Toxicol. (2011) ;49(8):1764-9.
  33. Rodrigues-Lima F, Dairou J, Laurieri N, Busi F, Dupret JM.”Fifth International Workshop on Arylamine N- University Paris Diderot, Paris, France, 1-3 September 2010.” Pharmacogenomics. (2011);12(8):1091-3
  34. Pluvinage B, de la Sierra-Gallay IL, Kubiak X, Xu X, Dairou J, Dupret JM, Rodrigues-Lima F. “The Bacillus anthracis arylamine N-acetyltransferase ((BACAN)NAT1) that inactivates sulfamethoxazole, reveals unusual structural features compared with the other NAT isoenzymes.“ FEBS Lett. (2011) 15; 585(24):3947-52.
  35. Sliwa D, Dairou J, Camadro JM, Santos R. “Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells.“ Biochem J. (2012); 1;441(3):945-53.
  36. Kubiak X, Dervins-Ravault D, Pluvinage B, Chaffotte AF, Gomez-Valero L, Dairou J, Busi F, Dupret JM, Buchrieser C, Rodrigues-Lima F. “Characterization of an acetyltransferase that detoxifies aromatic chemicals in Legionella pneumophila“ Biochem J. (2012);445(2):219-28.
  37. Planque C, Dairou J, Noll C, Bui LC, Ripoll C, Guedj F, Delabar JM, Janel N. “ Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain.” J Mol Neurosci. (2012).
  38. Joly-Amado A, Denis RG, Castel J, Lacombe A, Cansell C, Rouch C, Kassis N, Dairou J, Cani PD, Ventura-Clapier R, Prola A, Flamment M, Foufelle F, Magnan C, Luquet S. “ Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning.“ EMBO J. (2012) 14;31(22):4276-88.
  39. Kubiak X, Dairou J, Dupret JM, Rodrigues-Lima F. “Crystal structure of arylamine N-acetyltransferases: insights into the mechanisms of action and substrate selectivity.” Expert Opin Drug Metab Toxicol. (2013); 9(3):349-62.
  40. Tlili A, Jacobs F, de Koning L, Mohamed S, Bui LC, Dairou J, Belin N, Ducros V, Dubois T, Paul JL, Delabar JM, De Geest B, Janel N. “Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice.” Biochim Biophys Acta. (2013); 1832(6):718-728.
  41. Laureti L, Selva M, Dairou J, Matic I. “Reduction of dNTP levels enhances DNA replication fidelity in vivo.” DNA Repair (Amst). (2013) 1;12(4):300-5.
  42. Medjkane S, Perichon M, Marsolier J, Dairou J, Weitzman J. “Theileria Induces Oxidative Stress and HIF1α Activation that are Essential for Host Leukocyte Transformation” Oncogene (2013) in press.
  43. Ripoll C, Dairou J, Stora S, Delabar JM, Janel N. “Plasma nitrate levels are increased in adult Down syndrome patients” Biomarkers (2013) 18(4):373-4.
  44. Bui LC, Manaa A, Xu X, Duval R, Busi F, Dupret JM, Rodrigues-Lima F, Dairou J. “Acrolein, an α,β-unsaturated aldehyde, irreversibly inhibits the acetylation of aromatic amine xenobiotics by human arylamine N-acetyltransferase 1” Drug Metab Dispos. (2013) 41(7):1300-5.
  45. Cocaign A, Bui LC, Silar P, Chan Ho Tong L, Busi F, Lamouri A, Mougin C, Rodrigues-Lima F, Dupret JM, Dairou J. “Biotransformation of Trichoderma spp. and their tolerance to aromatic amines, a major class of pollutants.” Appl Environ Microbiol. (2013) 79(15):4719-26.
  46. Laurieri N, Egleton JE, Varney A, Thinnes CC, Quevedo CE, Seden PT, Thompson S, Rodrigues-Lima F, Dairou J, Dupret JM, Russell AJ, Sim E. ” A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1.” PLoS One (2013) 5;8(8):e70600.
  47. Moullé VS, Le Foll C, Philippe E, Kassis N, Rouch C, Marsollier N, Bui LC, Guissard C, Dairou J, Lorsignol A, Pénicaud L, Levin BE, Cruciani-Guglielmacci C, Magnan C. ” Fatty Acid Transporter CD36 Mediates Hypothalamic Effect of Fatty Acids on Food Intake in Rats.” PLoS One (2013) 6;8(9):e74021.
  48. Gourdain S, Dairou J, Denhez C, Bui LC, Rodrigues-Lima F, Janel N, Delabar JM, Cariou K, Dodd RH. “Development of DANDYs, New 3,5-Diaryl-7-azaindoles Demonstrating Potent DYRK1A Kinase Inhibitory Activity.” J Med Chem. (2013) 12;56(23):9569-85.
  49. Garrel G, Simon V, Denoyelle C, Ishaq M, Rouch C, Dairou J, Magnan C, Migrenne S, Cruciani-Guglielmacci C, Cohen-Tannoudji J. “Unsaturated Fatty Acids Disrupt Smad Signaling in Gonadotrope Cells Leading to Inhibition of FSHβ Gene Expression.” Endocrinology. (2014);155(2):592-604.
  50. Xu X, Mathieu C, Boitard SE, Dairou J, Dupret JM, Agbulut O, Rodrigues-Lima F. “Skeletal muscle glycogen phosphorylase is irreversibly inhibited by mercury: Molecular, cellular and kinetic aspects.” FEBS Lett. 2014 Jan 3;588(1):138-42.
  51. Bui LC, Tabouy L, Busi F, Dupret JM, Janel N, Planque C, Delabar JM, Rodrigues-Lima F, Dairou J. “A high-performance liquid chromatography assay for Dyrk1a, a Down syndrome-associated kinase.” Anal Biochem. (2014) 15;449:172-8.
  52. Ramond E, Gesbert G, Rigard M, Dairou J, Dupuis M, Dubail I, Meibom K, Henry T, Barel M, Charbit A. “Glutamate utilization couples oxidative stress defense and the tricarboxylic Acid cycle in francisella phagosomal escape.” PLoS Pathog. (2014) 10(1):e1003893.
  53. Laurieri N, Egleton J, Stanley L, Dairou J, Russell A, Dupret JM, Sim E, and Rodrigues-Lima F. “ From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: Impact of folic acid on the activity of human NAT1 and its murine homologue mNAT2″ PLoS One (2014); 13;9(5):e96370.
  54. Gesbert G, Ramond E, Tros F, Dairou J, Frapy E, Barel M, Charbit A. ” Importance of branched-chain amino acid utilization in Francisella intracellular adaptation.” Infect Immun. (2015); 83(1):173-83.
  55. Cocaign A, Kubiak X, Xu X, Garnier G, Li de la Sierra-Gallay I, Chi-Bui L, Dairou J, Busi F, Abuhammad A, Haouz A, Dupret JM, Herrmann JL, Rodrigues-Lima F. ” Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition.” Acta Crystallogr D Biol Crystallogr. (2014); 70(Pt 11):3066-79.
  56. Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A. ” Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues.” J Biol Chem. (2015); 16; 290(3):1885-97.
  57. Duval R, Bui LC, Berthelet J, Dairou J, Mathieu C, Guidez F, Dupret JM, Cools J, Chomienne C, Rodrigues-Lima F. ” A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2).” Sci Rep. (2015) Jun 4; 5:10750.
  58. Chan Ho Tong L, Dairou J, Bui LC, Bouillon J, Rodrigues-Lima F, Dupret JM, Silar P. ” Screen for soil fungi highly resistant to dichloroaniline uncovers mostly Fusarium species.” Fungal Genet Biol. (2015); 81:82-7.
  59. Mihoub M, Abdallah J, Gontero B, Dairou J, Richarme G. ” The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal.” Biochem Biophys Res Commun. (2015) Aug 7; 463 (4):1305-10.
  60. Gemble S, Ahuja A, Buhagiar-Labarchède G, Onclercq-Delic R, Dairou J, Biard DS, Lambert S, Lopes M, Amor-Guéret M. “Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.” PLoS Genet. (2015) Jul 16; 11 (7):e1005384.
  61. Messaoudi N, Gautier V, Dairou J, Mihoub M, Lelandais G, Bouloc P, Landoulsi A, Richarme G. “Fermentation and Alternative Respiration Compensate for NADH Dehydrogenase Deficiency in a Prokaryotic Model of DJ-1 Associated Parkinsonism.” (2015) 15. doi: 10.1099/mic.0.000181.
  62. Milesi, V., Guyot, F., Brunet, F., Richard, L., Recham, N., Benedetti, M., Dairou, J., Prinzhofer, A. “Formation of CO2, H2 and condensed carbon from siderite dissolution in the 200-300°C range and at 50MPa” Geochimica et Cosmochimica Acta (2015) volume 154, issue , pp. 201 – 211.
  63. Dhers L, Pietrancosta N, Ducassou L, Ramassamy B, Dairou J, Jaouen M, André F, Mansuy D, Boucher JL. “Spectral and 3D model studies of the interaction of orphan human cytochrome P450 2U1 with substrates and ligands” Biochim Biophys Acta. (2016) pii: S0304-4165(16)30265-3. doi: 10.1016/j.bbagen.2016.07.018
  64. Mathieu A, Fleurier S, Frénoy A, Dairou J, Bredeche MF, Sanchez-Vizuete P, Song X, Matic I. “Discovery and Function of a General Core Hormetic Stress Response in E. coli Induced by Sublethal Concentrations of Antibiotics.” Cell Rep. (2016) 27;17(1):46-57. doi: 10.1016/j.celrep.2016.09.001.
  65. Richarme G, Dairou J. “Parkinsonism-associated protein DJ-1 is a bona fide deglycase.” Biochem Biophys Res Commun. (2017) 29;483(1):387-391. doi: 10.1016/j.bbrc.2016.12.134.
  66. Mamadou G, Charrueau C, Dairou J, Limas Nzouzi N, Eto B, Ponchel G. “Increased intestinal permeation and modulation of presystemic metabolism of resveratrol formulated into self-emulsifying drug delivery systems.” Int J Pharm. (2017) 17;521(1-2):150-155. doi: 10.1016/j.ijpharm.2017.02.036.
  67. Haddadi-Guemghar H, Tlili A, Dairou J, Paul JL, Madani K, Janel N.”Effect of lyophilized prune extract on hyperhomocysteinemia in mice.” Food Chem Toxicol. (2017) 10;103:183-187. doi: 10.1016/j.fct.2017.03.018.
  68. Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M. Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion. Mol Metab. (2017) 26;6(4):340-351. doi: 10.1016/j.molmet.2017.01.009.
  69. London J, Rouch C, Bui LC, Assayag E, Souchet B, Daubigney F, Medjaoui H, Luquet S, Magnan C, Delabar JM, Dairou J, Janel N. Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues. Mol Neurobiol. 2017 May 25. doi: 10.1007/s12035-017-0591-6.
  70. Richarme G, Liu C, Mihoub M, Abdallah J, Leger T, Joly N, Liebart JC, Jurkunas UV, Nadal M, Bouloc P, Dairou J, Lamouri A. Guanine glycation repair by DJ-1/Park7 and its bacterial homologs. Science. 2017 Jun 8. pii: eaag1095. doi: 10.1126/science.aag1095.
  71. Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso PV, Tangy F, Vidalain PO. “Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response.” Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00383-17. doi: 10.1128/AAC.00383-17.
  72. Simon V, Avet C, Grange-Messent V, Wargnier R, Denoyelle C, Pierre A, Dairou J, Dupret JM, Cohen-Tannoudji J. “ Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway.” Endocrinology. 2017 Oct 1;158(10):3200-3211. doi: 10.1210/en.2017-00374.
  73. Campana M, Bellini L, Rouch C, Rachdi L, Coant N, Butin N, Bandet CL, Philippe E, Meneyrol K, Kassis N, Dairou J, Hajduch E, Colsch B, Magnan C, Le Stunff H. “nhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats.” Mol Metab. 2018 Nov 7. pii: S2212-8778(17)30690-7. doi: 10.1016/j.molmet.2017.10.013. [Epub ahead of print]
  74. Neumann F, Gourdain S, Albac C, Dekker AD, Bui LC, Dairou J, Schmitz-Afonso I, Hue N, Rodrigues-Lima F, Delabar JM, Potier MC, Le Caër JP, Touboul D, Delatour B, Cariou K, Dodd RH. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. doi: 10.1038/s41598-018-20984-z.
  75. Metghalchi S, Vandestienne M, Haddad Y, Esposito B, Dairou J, Tedgui A, Mallat Z, Potteaux S, Taleb S. Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet. PLoS One. 2018 Mar 1;13(3):e0193737. doi: 10.1371/journal.pone.0193737. eCollection 2018.
  76. Machover D, Goldschmidt E, Mollicone R, Haghighi-Rad F, Desterke C, Gaston-Mathé Y, Saffroy R, Boucheix C, Dairou J. Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5′-Phosphate and Folinic Acid in Tandem. J Pharmacol Exp Ther. 2018 Aug;366(2):238-243. doi: 10.1124/jpet.118.249367.
  77. Richarme G, Abdallah J, Mathas N, Gautier V, Dairou J. Further characterization of the Maillard deglycase DJ-1 and its prokaryotic homologs, deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL. Biochem Biophys Res Commun. 2018 Jun 22. pii: S0006-291X(18)31376-7. doi: 10.1016/j.bbrc.2018.06.064.
  78. Laurans L, Venteclef N, Haddad Y, Chajadine M, Alzaid F, Metghalchi S, Sovran B, Denis RGP, Dairou J, Cardellini M, Moreno-Navarrete JM, Straub M, Jegou S, McQuitty C, Viel T, Esposito B, Tavitian B, Callebert J, Luquet SH, Federici M, Fernandez-Real JM, Burcelin R, Launay JM, Tedgui A, Mallat Z, Sokol H, Taleb S. Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health. Nat Med. 2018 Jun 25. doi: 10.1038/s41591-018-0060-4.
  79. Larigot L, Juricek L, Dairou J, Coumoul X. AhR signaling pathways and regulatory functions. Biochim Open. 2018 Jun 11;7:1-9. doi: 10.1016/j.biopen.2018.05.001. eCollection 2018 Dec. Review.
  80. London J, Ndiaye FK, Bui LC, Souchet B, Daubigney F, Magnan C, Luquet S, Dairou J, Janel N, Rouch C. Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain. Mol Neurobiol. 2018 Sep 20. doi: 10.1007/s12035-018-1323-2.
  81. Souchet B, Duchon A, Gu Y, Dairou J, Chevalier C, Daubigney F, Nalesso V, Créau N, Yu Y, Janel N, Herault Y, Delabar JM. Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models. Sci Rep. 2019 Mar 8;9(1):3914. doi: 10.1038/s41598-019-40328-9.
  82. Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N. Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice. Acta Neuropathol Commun. 2019 Mar 18;7(1):46. doi: 10.1186/s40478-019-0678-6.
  83. Machover D, Rossi L, Hamelin J, Desterke C, Goldschmidt E, Chadefaux-Vekemans B, Bonnarme P, Briozzo P, Kopečný D, Pierigè F, Magnani M, Mollicone R, Haghighi-Rad F, Gaston-Mathé Y, Dairou J, Boucheix C, Saffroy R. Effects in Cancer Cells of the Recombinant l-Methionine Gamma-Lyase from Brevibacterium aurantiacum. Encapsulation in Human Erythrocytes for Sustained l-Methionine Elimination. J Pharmacol Exp Ther. 2019 Jun;369(3):489-502. doi: 10.1124/jpet.119.256537. Epub 2019 Apr 2.
  84. Girard B, Tuduri P, Moreno MP, Sakkaki S, Barboux C, Bouschet T, Varrault A, Vitre J, McCort-Tranchepain I, Dairou J, Acher F, Fagni L, Marchi N, Perroy J, Bertaso F. The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures. Neurobiol Dis. 2019 Sep;129:13-28. doi: 10.1016/j.nbd.2019.04.016. Epub 2019 Apr 30.
  85. Hayek S, Pietrancosta N, Hovhannisyan AA, Alves de Sousa R, Bekaddour N, Ermellino L, Tramontano E, Arnould S, Sardet C, Dairou J, Diaz O, Lotteau V, Nisole S, Melikyan G, Herbeuval JP, Vidalain PO. Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition. Eur J Med Chem. 2020 Jan 15;186:111855. doi: 10.1016/j.ejmech.2019.111855. Epub 2019 Nov 6.
  86. Oshima M, Pechberty S, Bellini L, Göpel SO, Campana M, Rouch C, Dairou J, Cosentino C, Fantuzzi F, Toivonen S, Marchetti P, Magnan C, Cnop M, Le Stunff H, Scharfmann R. Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity. Diabetologia. 2020 Feb;63(2):395-409. doi: 10.1007/s00125-019-05046-x.