Biological chemistry

+33 1 76 53 42 19, room R125

Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques (LCBPT) – CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Curriculum Vitae

2006-2017 – Membre de l’équipe de chimie bioinorganique supramoléculaire, Pr. Olivia Reinaud: “Synthesis of novel calix[6]cryptand ligands and their corresponding metal complexes, spectroscopic studies, host-guest behaviour and O₂ activation”.

2003-2006 – Enseignement à plein temps (302.5 heures / an)

2000-2003 – Membre de l’équipe du Dr. Jiri Kozelka: “Study of diamineplatinum(II)GpG chelate complexes”.

1993-2000 – Membre de l’équipe du Pr. Jean-Claude Chottard. “Copper complexes of polyimidazole and polyimidazol-sulfur ligands; model compounds for nitrile hydratase”.

Depuis 1993 – Maître de Conférences, UMR-CNRS 8601, Université Paris Descartes

1992-1993 – Séjour post-doctoral au laboratoire du Dr. J.-C. Marchon, CEA, DRFM, Grenoble, France: “Study of reaction intermediates formed during the asymmetric catalysis of an epoxydation reaction by Ru-chiroporphyrins”.

1987-1992 – Ph.D. au laboratoire du Pr. J. M. Mayer, University of Washington, Seattle, U.S.A.: “Studies on Oxygen Atom and Nitrene Group Transfer: Reactions of Low Valent W(II) and Mo(II) Complexes with Amines; Mechanistic Studies on Nitrene or Oxygen Atom Transfer of Aziridines and Epoxides to W(II) Complexes; Intermetal Oxygen and Chlorine Atom Transfer Between W, Mo and Re.”

1985-1987 – Bachelor’s Degree en Biochimie, University of California, San Diego, U.S.A..

1982-1984 – Vor-Diplom en Chimie, Universität zu Köln, Germany.

Publications

G. De Leener, F. Evoung-Evoung, A. Lascaux, J. Mertens, A.- G. Porras-Gutierrez, N. Le Poul, C. Lagrost,D. Over, Y. R. Leroux,F. Reniers,P. Hapiot,Y. Le Mest, I. Jabin, O. Reinaud, J. Am. Chem. Soc., 2016, 138, 12841–12853. Immobilization of Monolayers Incorporating Cu Funnel Complexes onto Gold Electrodes. Application to the Selective Electrochemical Recognition of Primary Alkylamines in Water.

J.-N. Rebilly, B.,Colasson, O.Bistri, D. Over, O.Reinaud, Chem. Soc. Rev., 2015, 44, 467-489. Biomimetic Cavity-Based Metal Complexes.

D. Over, X. Zeng, C. Bornholdt, J. Marrot, O. Reinaud, Chem., 2013, 52, 14089-14095. Coordination of Lead(II) in the Supramolecular Environment Provided by a “Two-Story” Calix[6]arene-based N6 Ligand.

N. Menard, D. Over, O. Reinaud, B. Colasson, Tet. Lett., 2013, 54, 3398-3401. Proton-induced motion in a molecular cup-and-ball Zinc funnel complex.

Zeng, C. Bornholdt, D. Over, O. Reinaud, Org. Lett., 2011, 13, 5660-5663. Synthesis of ”Two-story” Calix[6]aza-cryptands.

D. Over, A. de la Lande, X. Zeng, O. Parisel, O. Reinaud, Inorg. Chem., 2009, 48, 4317-4330. Replacement of a Nitrogen by a Phosphorus Donor in Biomimetic Copper Complexes: a Surprising and Informative Case Study with Calix[6]arene-Based Cryptands.

G. Izzet, X. Zeng, D. Over, B. Douziech, J. Zeitouny, M. Giorgi, I. Jabin, Y. Le Mest, O. Reinaud, Inorg. Chem., 2007, 46, 375-377. Insights into the electronic properties of a Cu(II) center embedded in the PN₃ cap of a calix[6]arene-based ligand.

D. Over, G. Bertho, M.-A.Elizondo-Riojas, J. Kozelka, J. Biol. Inorg. Chem., 2006, 11, 139-152. Fixing the conformations of diamineplatinum(II)-GpG chelates : NMR and CD signatures of individual rotamers.

S. Benazeth, J. Purans, D. E. Over, J.C. Chottard, Journal de Physique IV, 1997, 7, 639-640. Cu polyimidazole thioether complexes: Comparison of RDF’s reconstructed from XAFS and XRD data.

D. Over, M. Bardet, J. C. Marchon, R. Ramasseul, 1995, Magn. Res. Chem., 33, 224-227. Complete ¹H And ¹³C NMR Assignments of 2 Steroid 5,6-beta-Epoxides Using 1D-TOCSY And 2D-HMQC-TOCSY Experiments.

M. Veyrat, O. Maury, F. Faverjon, D. E. Over, J. C. Marchon, R. Ramasseul, I. Turowska-Tyrc, R. Scheidt, Angew. Chem. Int. Ed. Engl., 1994, 33, 220-223. Chiroporphyrins: An Approach to Asymmetric Catalysts with Stereocenters Near the Plane of the Porphyrin Ring.

D. E. Over, J. M. Mayer, Polyhedron. 1993, 12, 2593-2602. Amine Complexes of Tungsten(II) and Molybdenum(II) – M(NH₂R)Cl₂(PMePh₂)₃ and M(NH₂CH₂CH₂NH₂)Cl₂(PMePh₂)₂.

D. . E. Over, S. C. Critchlow, J. M. Mayer, Inorg. Chem. 1992, 31, 4643-4648. Oxygen and chlorine atom transfer between tungsten, molybdenum, and rhenium complexes. Competition between one- and two-electron pathways.

L. M. Atagi, D. E. Over, D. R. McAlister, J. M. Mayer, J. Am. Chem. Soc., 1991, 113, 870-874. On The Mechanism of Oxygen Atom or Nitrene Group Transfer in Reactions of Epoxides And Aziridines With Tungsten(II) Compounds.