Publications

“The catalytic mechanism of the RNA-methyltransferase METTL3”, I. Corbeski, P. Andrés Vargas-Rosales, R. Kumar Bedi, J. Deng, D. Coelho, E. Braud, L. Iannazzo, Y. Li, D. Huang, M. Ethève-Quelquejeu, Q. Cui, A. Caflisch, eLife, 2023, doi.org/10.7554/eLife.92537.1

“Synthesis of Bisubstrate Analogues for RNA Methylation Studies using two Transition Metal-Catalyzed Reactions” Coelho, Dylan; Le Corre, Laurent; Bartosik, Karolina; Iannazzo, Laura; Braud, Emmanuelle; Etheve-Quelquejeu, Mélanie, Chem. Eur. J. 2023, https://doi.org/10.1002/chem.202301134 

“Ruthenium-Catalyzed Cycloaddition for Introducing Chemical Diversity in Second Generation β-Lactamase Inhibitors”, Flavie Bouchet, Jean-Philippe Barnier, Ines Sayah, Youcef Bagdad, Maria A. Miteva, Michel Arthur, Mélanie Ethève-Quelquejeu, Laura Iannazzo ChemMedChem. 2023, https://doi.org/10.1002/cmdc.202300077

“Enzymatic synthesis of vancomycin-modified DNA” C. Figazzolo, F. Bonhomme, S. Saidjalolov, M. Ethève-Quelquejeu, M. Hollenstein*, Molecule, 2022, doi.org/10.3390/molecules27248927 

“Traceless Staudinger Ligation to Access to Stable Aminoacyl- or Peptidyl-dinucleotides” C. Kitoun, S. Saidjalolov, D. Bouquet, F. Djago, Q. Blancart Remaury, B. Sargueil, P. Poinot, Pauline; M. Etheve-Quelquejeu, L. Iannazzo, ACS Omega., 2022, accepted.

“Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis”, Rietmeyer, L.; Li de la Sierra-Gallay, I.; Schepers, G.; Dorchêne, D.; Iannazzo, L.; Patin, D.; Touzé, T.; van Tilbeurgh, H.; Herdewijn, P.; Etheve-Quelquejeu, M.; Fonvielle, M., Nucleic Acids Research, 2022, Accepted

“Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase”, Vincent Meynier, Laura Iannazzo, Marjorie Catala, Stephanie Oerum, Emmanuelle Braud, Colette Atdjian, Pierre Barraud, Matthieu Fonvielle, Carine Tisné, Mélanie Ethève-Quelquejeu Nucleic Acids Research, 2022, gkac354, https://doi.org/10.1093/nar/gkac354

“Modulation of the Specificity of Carbapenems and Diazabicyclooctanes for Selective Activity against Mycobacterium tuberculosis”, Jean-Philippe Barnier, Saidbakhrom Saidjalolov, Flavie Bouchet, Louis Mayer, Zainab Edoo, Inès Sayah, Laura Iannazzo, Mélanie Ethève-Quelquejeu, Jean-Luc Mainardi, Emmanuelle Braud, Michel Arthur Antimicrob. Agents Chemother. 2022, https://doi.org/10.1128/aac.02357-21

• “Traceless Staudinger ligation to introduce chemical diversity on β-lactamase inhibitors of second generation”, Bouchet F.; Atze H.; Arthur M.; Etheve-Quelquejeu* M; Iannazzo* L., Org. Lett., 2021, accepted. 
• “Click and Release Chemistry for Activity-based Purification of b-lactam targets”, S. Saidjalolov, E. Braud, Z. Edoo, L. Iannazzo, F. Rusconi, M. Riomet, A. Sallustrau, F. Taran, M. Arthur,* M. Fonvielle*, M. Etheve-Quelquejeu*,  Chem. Eur. J., 2021, DOI:10.1002/chem.202100653. 
• “Partition of tRNA^Gly isoacceptors between protein and cell-wall peptidoglycan synthesis in Staphylococcus aureus”, Rietmeyer, L.; Fix-boulier, N.; Le Fournis, C.; Iannazzo, L.; Kitoun, C.; Patin, D.; Mengin-lecreulx, D.; Etheve-Quelquejeu, M.; Arthur*, M.; Fonvielle*, M., Nucleic Acid Res. 2021, doi.org/10.1093/nar/gkaa1242.
•  “Synthesis of carbapenems containing peptidoglycan-mimetics and inhibition of the cross-linking activity of a transpeptidase of the L,D specificity”, S. Saidjalolov, Z. Edoo, M. Fonvielle, L. Mayer, L. Iannazzo, M. Arthur,* M. Etheve-Quelquejeu,* E. Braud*. Chem. Eur. J., 2021, doi.org/10.1002/chem.202004831.

• “Phosphine-Mediated Bioconjugation of 3’-end of RNA”, C. Kitoun, M. Fonvielle, F. Djago, N. Sakkas, M. Lefresne, Q. Blancart Remaury, P. Poinot, M. Arthur, M. Etheve-Quelquejeu, L. Iannazzo, Org. Lett. 2020, DOI:10.1021/acs.orglett.0c02982.
• “Design, synthesis and biological evaluations of covalent inhibitors of Focal Adhesion Kinase (FAK) against human malignant glioblastoma”, Li Bo; Li, Yongliang; Tomkiewicz-Raulet, C. ; Dao, P. ; Lietha, D.; Yen-Pon, E.; Du, Z.; Coumoul, X.;  Garbay, C.; Etheve-Quelquejeu, M.; Chen, H., 2020, J. Med. Chem., Doi.org/10.1021/acs.jmedchem.0c01059.
• “Design and Synthesis of a Peptide Derivative of Ametantrone Targeting the Major Groove of the d(GGCGCC)2 Palindromic Sequence”, A; Ongaro, G. Ribaudo, E. Braud, M. Etheve-Quelquejeu, M. De Franco, C. Garbay, L. Demange, N. Gresh, G. Zagotto, 2020, New Journal of Chemistry, doi:10.1039/C9NJ03817E 
• “Diazabicyclooctane functionalization for inhibition of β-lactamases from enterobacteria“. Flavie Bouchet, Heiner Atze, Matthieu Fonvielle, Zainab Edoo, Michel Arthur, Mélanie Ethève-Quelquejeu, Laura Iannazzo; Journal of Medicinal Chemistry,  2020, 63, 10, 5257–5273 https://doi.org/10.1021/acs.jmedchem.9b02125
• “Synthesis of triazole-linked SAM-adenosine conjugates: functionalization of adenosine at N-1 or N-6 position without protecting groups.” Colette Atdjian, Dylan Coelho, Laura Iannazzo, Mélanie Ethève-Quelquejeu and Emmanuelle Braud Molecules, 2020, 25, 3241. doi.org/10.3390/molecules25143241.
• “Raman Reporters Derived From Aryl Diazonium Salts for SERS Encoded-Nanoparticles”, Y.Luo, Y. Xiao, D. Onidas, I. Kherbouche, S. Mahouche, T. Brulé, N. Félidj, L. Iannazzo, M. Ethève-Quelquejeu, F. Gazeau, C. Mangeney, 2020, Chem. Comm.doi.org/10.1039/D0CC02842H. 
• “The neurobehavioral effects of the designer drug naphyrone – an experimental investigation with pharmacokinetics and concentration/effect relationship in mice”, B. Mégarbane, Ca. Gamblin, O. Roussel1,  El. Bouaziz-Amar1, L. Chevillard, J. Callebert, H. Chen, G. Morineau, J-L. Laplanche, M. Etheve-Quelquejeu, M. E. Liechti, N. Benturquia, 2020, Psychopharmacology, https://doi.org/10.1007/s00213-020-05510-2.
  

• “Microwave-assisted synthesis of 2,5-disubstituted pyrimidine derivatives via Buchwald-Hartwig amination.” Li B.; Yen-Pon E.; Etheve-Quelquejeu M. , Garbay C.; Chen H.  Tetrahedron Letter. 2019, accepted. 
• « Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat » L. A. Atehortua-Martinez, C. Masniere, P. Campolongo, S. Chasseigneaux, J. Callebert, C. Zwergel, A. Mai, J-L. Laplanche, H. Chen, M. Etheve-Quelquejeu, B. Mégarbane, N. Benturquia, Journal of Psychopharmacology, 2019, doi: 10.1177/0269881118822151.
• “Negative impact of carbapenem methylation on the reactivity of β-lactams for cysteine acylation revealed by quantum calculations and kinetic analyses”, N. Bhattacharjee, S. Triboulet, V. Dubée, M. Fonvielle, Z. Edoo, J-E. Hugonnet, M. Ethève-Quelquejeu, J-P. Simorre, M. J. Field, M. Arthur, C. M. Bougault, Antimicrob. Agents Chemother., 2019, DOI: 10.1128/AAC.02039-18.
• « Bisubstrate Analogues as Structural Tools to Investigate m6A Methyltransferase Active Sites », S. Oeruma, M. Catalaa, C. Atdjian, F. Brachetc, L. Ponchond, P. Barrauda, L. Iannazzo, L. D., E. Braud, M. Ethève-Quelquejeu and C. Tisné, RNA Biology, 2019, accepted. (I.F. 5.2)
• “Tryptophan fluorescence quenching in β-lactam-interacting proteins is modulated by the structure of intermediates and final products of the acylation reaction” Triboulet, S.; Edoo, Z.; Compain, F.; Ourghanlian, C.; Dupuis, A.; Dubée, V.; Sütterlin, L.; Atze, H.; Etheve-Quelquejeu, M.; Hugonnet, J-E.; Arthur, M., ACS Infectious Diseases, 2019, accepted.  (I.F. 4.3)

• “Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25”, M. Sarkis, M.A. Miteva, M. Chiara Dasso Lang, M. Jaouen, M-A. Sari, M-O. Galcéra, M. Ethève-Quelquejeu, C. Garbay, G. Bertho,  E. Braud, PROTEINS: Structure, Function, and Bioinformatics, , 2017, 55, 13553-13557.
•  “Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity”, P. Dao, D. Lietha, M. Etheve-Quelquejeu, C. Garbay, H. Chen, Bioorg. Med. Chem. Lett., 2017, 27(8):1727-1730.

• “Routes of synthesis of carbapenems for optimizing both the inactivation of L,D-transpeptidase Ldt_Mt1 of Mycobacterium tuberculosis and the stability towards hydrolysis by β-lactamase BlaC”, L. Iannazzo, D. Soroka, S. Triboulet, M. Fonvielle, F. Compain, V. Dubée, J-L. Mainardi, J-E.Hugonnet, E. Braud, M. Arthur, M. Etheve-Quelquejeu, J. Med. Chem., 2016, 59, 7, 3427-3438.
• “Synthesis of Multifunctionalized 2-Iminothiazolidin-4-ones and Their 2-Arylimino Derivatives”, synthesis, L. Le Corre, M. Chiara Dasso Lang, C. Garbay, C. Gravier-Pelletier, P. Busca, M.Ethève-Quelquejeu, E. Braud, Synthesis, 2016; 48(24): 4569-4579.
• “Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes”, M. Fonvielle, N. Sakkas, L. Iannazzo, C. Le Fournis, D. Patin, D. Mengin-Lecreulx, A. El-Sagheer, E. Braud, S. Cardon, T. Brown, M. Arthur, M. Etheve-Quelquejeu, Angewandte Chem., 2016, 55, 13553–13557.

• « Critical impact of peptidoglycan precursor amidation on the activity of L,D-transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis » F. Ngadjeua, E. Braud, S. Saidjalolov, L. Iannazzo, D. Schnappinger, S. Ehrt, J-E. Hugonnet, D. Mengin-Lecreulx, D. Patin, M. Ethève-Quelquejeu, M. Fonvielle, M. Arthur, Chem. Eur. J., 2018, 24, 5743-5747.
• « Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes ». L. Iannazzo, M. Fonvielle, E. Braud, H. Hrebabecky, E. Prochazkova, R. Nencka, C. Mathé, M. Arthur, M. Etheve-Quelquejeu, Org. Biomol. Chem., 2018, 16, 1903 – 1911.
• “Synthesis of avibactam derivatives and activity on β-lactamases and peptidoglycan biosynthesis enzymes of mycobacteria”, Z. Edoo, L. Iannazzo, F. Compain, H. van Tilbeurgh, I. Li dela Sierra Galay, M. Fonvielle, M. Arthur, M. Ethève-Quelquejeu, and J-E. Hugonnet, Chem. Eur. J., 2018, 24, 8081-80-86.
• “Structure-based design, synthesis and characterization of the first irreversible inhibitor of Focal Adhesion Kinase” E. Yen-Pon, B. Li, M. Acebrón-Garcia de Eulate, C. Tomkiewicz-Raulet, J. Dawson, D. Lietha, M. C. Frame, X. Coumoul, C. Garbay, M. Etheve-Quelquejeu, H. Chen, ACS Chem. Biol., 2018, doi: 10.1021/acschembio.8b00250.
• « Synthesis of SAM-adenosine conjugates for the study of m⁶A-RNA methyltransferases». C. Atdjian, L. Iannazzo, E. Braud, M. Etheve-Quelquejeu, Eur. J. Org. Chem., 2018, doi.org/10.1002/ejoc.201800798.
• “Is the 3,4-methylendioxypyrovalerone/mephedrone combination responsible for enhanced stimulant effects? – A rat study with investigation of the effect/concentration relationships” Benturquia N., Chevillard L., Poiré C., Roussel O., Cohier C., Declèves X., Laplanche JL., Etheve-Quelquejeu M., Chen H., Mégarbane B., Psychopharmacology, 2018, doi.org/10.1007/s00213-018-4962-0.
• « Synthesis of lipid-carbohydrate-peptidyl-RNA conjugates to explore the limits imposed by the substrate specificity of cell wall enzymes on the acquisition of drug resistance», Fonvielle M., Bouhss A., Hoareau C., Patin D., Mengin-Lecreulx D., Iannazzo L., Sakkas N., El Sagheer A., Brown T., Ethève-Quelquejeu M., Arthur M., Chem. Eur. J., 2018, 24:14911-14915.

• 1 chapitre de livre : “Covalent functionalization of nucleic acids” Arthur & M. Etheve-quelquejeu, In Chemistry of Organo-Hybrids: Synthesis and Characterization of Functional Nano-Objects; Lacôte, E.; Charleux, B.; Copéret, C.; Eds.; Wiley-VCH, 2015.
• El Hage, K ; Piquemal, J-P ; Hobaika, Z ; Maroun, RG ; Gresh, N,, “Could the ‘Janus-like’ Properties of the Halobenzene CX Bond (X=Cl, Br) Be Leveraged to Enhance Molecular Recognition?” J. Comput. Chem., 2015, 36, 210-221 (IF 3.648)
• Iannazzo, L ; Laisné, G ; Fonvielle, M ; Braud, E; Herbeuval, J-P ; Arthur, M ; Etheve-Quelquejeu, M, “Synthesis of 3′-fluoro-tRNA analogues for exploring non-ribosomal peptide synthesis in bacteria“, ChemBioChem, 2015, 16, 477-486 (Selected as an VIP Manuscript, inside cover) (IF 3.088)
• Jarray, R ; Pavoni, S ; Borriello, L ; Allain, B ; Lopez, N ; Bianco, S ; Liu, W-Q ; Biard, D ; Demange, L ; Hermine, O ; Garbay, C ; Raynaud, F ; Lepelletier Y, “Disruption of phactr-1 pathway triggers pro-inflammatory and pro-atherogenic factors: New insights in atherosclerosis development.“, Biochimie, 2015, 118, 151-161 (IF 3.017)
• Liu, W-Q ; Borriello, L ; Allain, B ; Pavoni, S ; Hermine, O ; Garbay, C ; Raynaud, F ; Lepelletier, Y ; Demange, L, “New peptides structurally-related to VEGF-A₁₆₅ exon 7 and 8 encoded domains antagonize its binding to NRP-1 and VEGF-R1″, Int. J. Pept. Res. Ther., 2015, 21, 117-124 (IF 0.905)
• Dao, P ; Smith, N ; Tomkiewicz-Raulet, C ; Yen-Pon, E ; Camacho-Artacho, M ; Lietha, D ; Herbeuval, JP ; Coumoul, X ; Garbay, C ; Chen, H, “Design, Synthesis and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as Focal adhesion kinase inhibitors with antitumor activity”, J. Med. Chem., 2015, 58, 237-251 (IF 5.589)
• Iannazzo, L ; Benedetti, E ; Catala, M ; Etheve-Quelquejeu, M ; Tisné, C ; Micouin, L, “Monitoring of reversible boronic acid-diol interactions by fluorine NMR spectroscopy in aqueous media”, J. Org. Biomol. Chem., 2015, 13, 8817-8821 (IF 3.559)
• Wang, Q ; Rackers, JA ; He, C ; Qi, R ; Narth, C ; Lagardere, L ; Gresh, N ; Ponder, JW ; Piquemal, J-P ; Ren, PY, “General Model for Treating Short-Range Electrostatic Penetration in a Molecular Mechanics Force Field” J. Chem. Theory Comput., 2015, 11, 2609-2618 (IF 5.301)
• Dudev, T ; Devereux, M ; Meuwly, M ; Lim, C ; Piquemal, J-P ; Gresh, N, “Quantum-Chemistry Based Calibration of the Alkali Metal Cation Series (Li⁺-Cs⁺) for Large-Scale Polarizable Molecular Mechanics/Dynamics Simulations”, J. Comput. Chem., 2015, 36, 285-302 (IF 3.648)
• Gresh, N ; Sponer, JE ; Devereux, M ; Gkionis, K ; de Courcy, B ; Piquemal, J-P ; Sponer, J “Stacked and H-Bonded Cytosine Dimers. Analysis of the Intermolecular Interaction Energies by Parallel Quantum Chemistry and Polarizable Molecular Mechanics”, J. Phys. Chem. B., 2015, 119, 9477-9495 (IF 3.187)
• El Hage, K ; Piquemal, J-P ; Hobaika, Z ; Maroun, RG ; Gresh, N, “Approaching the double-faceted nature of the CX bond in halobenzenes with a bifunctional probe”, Chem. Phys. Lett., 2015, 637, 51-57 (IF 1.86)
• Gresh, N ; El Hage, K ; Goldwaser, E ; de Courcy, B ; Chaudret, R ; Perahia, D ; Narth, C ; Lagardere, L ; Lipparini, F ; Piquemal, J-P, “Addressing the issues of non-isotropy and non-additivity in the development of quantum chemistry-grounded polarizable molecular mechanics in Quantum Modeling of Complex Molecular Systems, Challenges and Advances in Computational Chemistry and Physics 2015, 21, J.-L. Rivail, M. Ruiz-Lopez, X. Assfeld, Editeurs.