Biologically active molecules and enabling technologies:
the future in motion?
Abstract. Medicinal chemistry is often limited to standard bench techniques involving well-known classical reactions. In the past years, in the frame of a collaboration with the group of Prof. Pawel Zajdel (Jagellonian University Medical College, Krakow, Poland), we have studied the synthesis of biologically active molecules, targeting specific serotoninergic receptors, and that could be used for the treatment of the cognitive deficits that are associated with dementia and Alzheimer’s disease.1 A major improvement was found in the use of novel technologies such as flow chemistry2 and mechanochemistry.3 Ball-milling was also used as a unique approach for the synthesis of biologically active silver(I) complexes featuring N-heterocyclic carbene ligands.4
References
1) Zajdel, P.; Grychowska, K.; Mogilski, S.; Kurczab, R.; Satała, G.; Bugno, R.; Kos, T.; Gołębiowska, J.; Malikowska-Racia, N.; Nikiforuk, A.; Chaumont-Dubel, S.; Bantreil, X.; Pawłowski, M.; Martinez, J.; Subra, G.; Lamaty, F.; Marin, P.; Bojarski, A. J.; Popik, P., J. Med. Chem. 2021, 64, 13279.
2) Drop, M.; Bantreil, X.; Grychowska, K.; Umuhire Mahoro, G.; Colacino, E.; Pawlowski, M.; Martinez, J.; Subra, G.; Zajdel, P.; Lamaty, F. Green Chem. 2017, 19, 1647.
3) a) Canale, V.; Frisi, V.; Bantreil, X.; Lamaty, F.; Zajdel, P., J. Org. Chem. 2020, 85, 10958. b) Canale, V.; Kotańska, M.; Dziubina, A.; Stefaniak, M.; Siwek, A.; Starowicz, G.; Marciniec, K.; Kasza, P.; Satała, G.; Duszyńska, B.; Bantreil, X.; Lamaty, F.; Bednarski, M.; Sapa, J.; Zajdel, P., Molecules 2021, 26, 3828.
4) Beillard, A.; Quintin, F.; Gatignol, J.; Retailleau, P.; Renaud, J.-L.; Gaillard, S.; Métro, T.-X.; Lamaty, F.; Bantreil, X., Dalton Trans. 2020, 49, 12592.