[Séminaires de l’UMR] Prof. Huw Davies, Emory University, USA

Calendar
When:
21 October 2022 @ 11 h 00 min – 12 h 00 min Europe/Paris Timezone
2022-10-21T11:00:00+02:00
2022-10-21T12:00:00+02:00
Where:
Amphi Delmas

CollaborativeApproach for Catalyst-Controlled Site-Selective and Enantioselective C-HFunctionalization.

One of the signature challenges of the NSF Center for Chemical Innovationon Selective C-H Functionalization (CCHF) has been the design of catalysts tocontrol site selective C-H functionalization reactions.  Dirhodium tetracarboxylates have been veryeffective in this regard because the carboxylate ligands self-assemble oncoordination to the dirhodium to generate high symmetry chiral catalysts ofdefined shape and size.  Thispresentation will describe the development of these catalysts and theirutilization in donor/acceptor carbene-induced C-H functionalization.  The synthetic utility of this methodology willbe illustrated by various applications to the synthesis of natural products andchiral scaffolds of pharmaceutical interest.

Background References

  1. H. M. L. Davies and K. Liao, “Dirhodium tetracarboxylates: privileged catalysts for selective intermolecular C-H functionalization” Nature Rev. Chem. 3, 347-360 (2019).
  2. H. M. L. Davies, “Finding opportunities from surprises and failures.  Development of rhodium-stabilized donor/acceptor carbenes and their application to catalyst-controlled C-H functionalization” J. Org. Chem. 84,  12722 (2019).