Laboratoire de Chimie et Biochimie
Pharmacologiques et Toxicologiques (LCBPT)
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06


Research Scientist, CNRS. HDR

Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques (LCBPT) – CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06

Curriculum Vitae


Academic and Professional Background :
2018 Habilitation, University Paris Descartes, Paris, France
2014- CNRS Researcher – UMR 8601, Université de Paris (former Paris Descartes University)
2013-2014 Post-Doctoral Fellow ESPCI Paris, Laboratoire de Chimie Organique, CNRS UMR 7084,  Paris (France)
2012-2013 Post-Doctoral Fellow University of Pittsburgh, Department of Chemistry, Pittsburgh PA (USA)
2011 PhD in Chemistry, University of Insubria, Dipartimento di Scienza ed Alta Tecnologia. Como (Italie).
Joint supervision with Sorbonne Université, Institut Parisien de Chimie Moléculaire (UMR 7201). Paris (France)
2008 Master in Chemistry (Laurea Specialistica in Scienze Chimiche) – University of Insubria,
Dipartimento di Scienza ed Alta Tecnologia. Como (Italie)




Thieme Chemistry Journals Award 2024

CNRS Bronze Medal


2019 ANR JCJC (PhotoChiraPhane)  class=
2019 IdEx “Dynamique Recherche” Université Paris Cité (projet pCpPhotoCat)  class=

Scientific interests:

Development of innovative methods to prepare and selectively functionalize planar chiral [2.2]paracyclophane derivatives. Synthesis and characterization of three-dimensional luminophores and RNA ligands based on the [2.2]paracyclophane scaffold.



  1. Wu, S.; Micouin L.; Benedetti E. “Practical access to planar chiral benzophenones derived from [2.2]paracyclophane” Synlett 2024, Accepted Manuscript, DOI: 10.1055/a-2284-4984.
  2. Flichot, H.; Sickinger, A.; Brom, J.; Lefeuvre, B.; Dorcet, V.; Guizouarn, T.; Cador, O.; Le Guennic, B.; Micouin, L.; Maury, O.; Benedetti, E.; Pointillart, F. “Magneto-structural correlation in lanthanide luminescent [2.2]Paracyclophane-based Single-Molecule Magnets  Dalton Trans. 2024, Accepted Manuscript, DOI:10.1039/D4DT00536H.
  3. Wu, S.; Felder, S.; Brom, J.; Pointillart, F.; Maury, O.; Micouin L.; Benedetti E. [2.2]Paracyclophanes: from selective functionalization to optical properties Adv. Optical. Mater. 2024, Accepted Manuscript
  4. Benedetti, E.; Delcourt, M.-L.; Felder, S.; Wu, S.; Brom, J.; Micouin, L. [2.2]Paracyclophanes: exploring new dimensions Actu. Chimique, 2024, 451, 18.
  5. Benedetti, E.; Micouin, L. Have spirocyclic scaffolds been properly utilized in recent drug discovery efforts? Expert Opin. Drug Discov. 2024, Just accepted. DOI: 10.1080/17460441.2024.2305735
  6. Brom, J.; Maruani, A.; Turcaud, S.; Lajnef, S.; Peyrot, F.; Micouin, L.; Benedetti, E. “[2.2]Paracyclophane-based coumarins: effective organo-photocatalysts for light-induced desulfonylation processes” Org. Biomol. Chem. 2024, 22, 59-64. DOI: 10.1039/D3OB01711G(Preprint ChemRxiv – DOI: 10.26434/chemrxiv-2023-n4ds3).
  7. Brom, J.; Maruani, A.; Micouin, L.; Benedetti, E. “Light-driven reductive cleavage of sulfonamides promoted by thiourea organophotosensitizers”. J. Org. Chem. 2023,  88, 5923. DOI: 10.1021/acs.joc.3c00296 (Preprint ChemRxiv – DOI: 10.26434/chemrxiv-2022-jvdqw)
  8. Fleurisson, C.; Graidia, N.; Foricher, Y.; Benedetti, E.; Micouin, L.;  “Intramolecular Buchwald-Hartwig N-Arylation of Bicyclic Hydrazines: Practical Access to Spiro[indoline-2,3′-piperidines]”  Org. Biomol. Chem. 2023, 21, 3542. DOI: 10.1039/D3OB00406F (Preprint ChemRxiv – DOI: 10.26434/chemrxiv-2022-rqsqc)
  9. Felder, S.; Delcourt, M.-L.; Rodríguez, R.; Favereau, L.; Jeanne Crassous, J.; Micouin, L.; Benedetti, E. “Compact CPL emitters based on a [2.2]paracyclophane scaffold: recent developments and future perspectives”, J. Mater. Chem. C 202311, 2053 DOI:
  10. S. Felder, C. Sagné, E. Benedetti, L. Micouin “Small-Molecule 3D Ligand for RNA Recognition: Tuning Selectivity through Scaffold Hopping” ACS Chemical Biology, 2022, 17, 3069. DOI:
  11. S. Felder, M.-L. Delcourt, M.H.E. Bousquet, D.  Jacquemin, R. Rodríguez, L. Favereau, J. Crassous, L. Micouin, E. Benedetti “Planar chiral analogues of PRODAN based on a [2.2]paracyclophane scaffold: Synthesis and photophysical studies”. J. Org. Chem. 2022, 87, 147-158 DOI:
  12. S. Wu, L.A. Galan, M. Roux, F. Riobe, B. Le Guennic, Y. Guyot, T. Le Bahers, L. Micouin, O. Maury, E. Benedetti “Tuning the excited state properties of [2.2]paracyclophane-based antennas to ensure efficient sensitization of lanthanide ions or singlet oxygen generation” Inorg. Chem. 2021, 60, 16194−16203. DOI:
  13. S. Felder, S. Wu, J. Brom, L. Micouin, E. Benedetti,  “Enantiopure planar chiral [2.2]paracyclophanes: Synthesis and applications in asymmetric organocatalysis” Chirality, 2021, 33, 506-527 DOI:
  14. S. Felder, L. Micouin, E. Benedetti “Para‐functionalization of N‐substituted 4‐amino[2.2]paracyclophanes by regioselective formylation” Eur. J. Org. Chem., 2021, 4015-4018. DOI:
  15. C. Fleurisson, E. Benedetti, L. Micouin Cyclic cis-1,3-Diamines Derived from Bicyclic Hydrazines: Synthesis and Applications Synlett 2021, 31, 858-874. DOI: 10.1055/s-0040-1707324
  16. M.-L.Delcourt, C. Reynaud, S. Turcaud, L. Favereau, J. Crassous, L. Micouin, E. Benedetti, 3D Coumarin Systems Based on [2.2]Paracyclophane: Synthesis, Spectroscopic Characterization, and Chiroptical Properties. J. Org. Chem. 2019, 84 , 888–899.
  17. M.-L. Delcourt, S. Felder, S. Turcaud, C. H. Pollok, C. Merten, L. Micouin, E. Benedetti,  Highly Enantioselective Asymmetric Transfer Hydrogenation: A Practical and Scalable Method To Efficiently Access Planar Chiral [2.2]Paracyclophanes. J. Org. Chem. 2019, 84 , 5369–5382.
  18. R. Piccardi, S. Turcaud, E. Benedetti, L. Micouin, Synthesis and Reactivity of Mixed Dimethylalkynylaluminum Reagents. Synthesis, 2019, 51 , 97–106. (Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue)
  19. M.-L. Delcourt, S. Simon, E. Benedetti, L.Micouin, Highly Enantioselective Desymmetrization of Centrosymmetric pseudo-para-Diformyl[2.2]paracyclophane via Asymmetric Transfer Hydrogenation ACS Catalysis, 2018, 8, 6612-6616
  20. E. Benedetti, M.-L. Delcourt, B. Gatin-Fraudet, S. Turcaud, L.Micouin “Synthesis and photophysical studies of through-space conjugated [2.2]paracyclophane-based naphthalene fluorophores” RSC Advances20177, 50472-50476
  21. R. Piccardi, A. Coffinet, S. Turcaud, E. Benedetti, L. Micouin, “Continuous flow synthesis of dimethylalkynylaluminum reagents.” Synthesis201648, 3272 .
  22. N. Duchemin, E. Benedetti, L. Bethge, S. Vonhoff, S. Klussmann, J.-J. Vasseur, J. Cossy, M. Smietana, S. Arseniyadis, “Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA.” Chem. Commun.201652, 8604.
  23. K. Amirbekyan, N. Duchemin, E. Benedetti, R. Joseph, A. Colon, S. Markarian, L. Bethge, S. Vonhoff, S. Klussmann, J. Cossy, J.-J. Vasseur, S. ; Arseniyadis, M. Smietana, “Design, Synthesis and Binding Affinity Evaluation of New Hoechst 33258 Derivatives for the Development of Sequence-specific DNA-based Asymmetric Catalysts.”ACS Catal20166, 3096.
  24. M.-L. Delcourt, S. Turcaud, E. Benedetti, L. Micouin, “Efficient and scalable kinetic resolution of racemic 4 formyl[2.2]paracyclophane via asymmetric transfer hydrogenation.” Adv. Synth. Catal2016358, 1213.
  25. L. Iannazzo, E. Benedetti, M. Catala, M. Etheve-Quelquejeu, C. Tisne, L. Micouin,
     “Monitoring of reversible boronic acid-diol interactions by fluorine NMR spectroscopy in aqueous media.” Org. Biomol. Chem. 201513, 8817.
  26. E. Benedetti, N. Duchemin, L. Bethge, S. Vonhoff, S. Klussmann, J.-J. Vasseur, J. Cossy, M. Smietana, S. Arseniyadis, “DNA-cellulose: An economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis.” Chem. Commun. 201551, 6076 (Front CoverSynfacts201511, 773).
  27. R. Barberon, E. Benedetti, J.-J. Vasseur, J. Cossy, S. Arseniyadis, M. Smietana, “Recent Developments in Alkyne Borylations.” Tetrahedron 201470, 843.
  28. J. Wang, E. Benedetti, L. Bethge, S. Vonhoff, S. Klussmann, J.-J. Vasseur, J. Cossy, M. Smietana, S. Arseniyadis, “DNA vs. mirror image DNA: A universal approach to tune the absolute configuration in DNA-based asymmetric catalysis” Angew. Chem. Int. Ed. 201352, 1156.
  29. E. Benedetti, A.B.E. Veliz M. Charpenay, L. S. Kocsis, K. M. Brummond, “Attachable solvatochromic fluorophores and bioconjugation studies” Org. Lett. 201315, 2578.
  30. L. S. Kocsis, E. Benedetti, K. M. Brummond “Microwave-assisted intramolecular dehydrogenative Diels-Alder reactions for the synthesis of functionalized naphthalenes/solvatochromic dyes,” J. Vis. Exp. 201374, e50511 (doi:
  31. L. S. Kocsis, E. Benedetti, K. M. Brummond. “A thermal dehydrogenative Diels-Alder reaction of styrenes for the concise synthesis of functionalized naphthalenes” Org. Lett. 201214, 4430 (Synfacts20128, 1199).
  32. E. Benedetti, L. S. Kocsis, K. M. Brummond “Synthesis and photophysical properties of a series of cyclopenta[b]naphthalene solvatochromic fluorophores” J. Am. Chem. Soc. 2012134, 12418 (Synfacts 20128, 1089).
  33.  Kitahara, K. ; Toma, T.; Shimokawa J ; Fukuyama, T ; Checked  by Benedetti, E.; Brummond, K. M. “Efficient Synthesis of Oxime Using O-TBS-N-Tosylhydroxylamine: Preparation of (2Z)-4-(Benzyloxy)but-2-enal Oxime” Org. Synth. 2012, 89, 480-490 DOI:
  34. E. Benedetti, M. Lomazzi, F. Tibiletti, J.-P. Goddard L. Fensterbank, M. Malacria, G. Palmisano, A. Penoni, “Synthesis of nitrogen contaning heterocycles via ring-closing ene-ene and ene-yne metathesis reactions. An easy access to 1- and 2-benzazepine scaffolds and five- and six-membered lactams” Synthesis 201244, 3523.
  35. E. Benedetti, A. Simonneau, A. Hours, H. Amouri, A. Penoni, G. Palmisano, M. Malacria, J.-P. Goddard L. Fensterbank, “(Pentamethylcyclopentadienyl)iridium dichloride dimer {[IrCp*Cl2]2}: a novel efficient catalyst for the cycloisomerizations of homopropargylic diols and N-tethered enynes” Adv. Synth. Catal. 2011353, 1908.
  36. E. Benedetti, G. Lemière, L.-L. Chapellet, A. Penoni, G. Palmisano, M. Malacria, J.-P. Goddard, L. Fensterbank, “Gold(I)-catalyzed cyclization of β-allenylhydrazones: an efficient synthesis of multisubtituted N-amino pyrroles” Org. Lett. 201012, 4396.
Book chapters
  1. Bicyclic 5-5 systems with one ring junction nitrogen atom: Two extra heteroatoms 2:0 Benedetti, E.; Micouin, L. Reference Collection in Chemistry, Molecular Science and Chemical Engineering Wiley, 2022. Volume 11, pp 145-173. DOI:10.1016/B978-0-12-409547-2.14935-2 
  2. Multicomponent reactions in natural product synthesis. Smietana, M.; Benedetti, E.; Bressy, C.; Arseniyadis S. in Efficiency in Natural Products Total Synthesis, (Eds. P.-Q. Huang, Z.-J. Yao, R. P. Hsung), Wiley, 2018 Chapter 8, pp 319-344.
  3. Recent applications of kagan’s reagent (SmI2) in natural product synthesis. Benedetti, E.; Bressy, C.; Smietana, M.; Arseniyadis, S. in Efficiency in Natural Products Total Synthesis, (Eds. P.-Q. Huang, Z.-J. Yao, R. P. Hsung), Wiley, 2018 Chapter 6, pp 273-295.
  4. Synthesis of polyketides. Bressy, C.; Smietana, M.; Benedetti, E.; Arseniyadis S. in From Biosynthesis to Total Synthesis, (Ed. A.L. Zografos), Wiley 2016, Chapter 2, pp 44-86.
  1. Functionalized naphthalene fluorophores, Brummond, K. M.; Kocsis, L. S.; Benedetti, E. U.S. Patent No 9,133,234 B2.  Publication date: 15/09/2015.
  2. Synthesis, structure and use of functionalized naphthalenes, Brummond, K. M.; Kocsis, L. S.; Benedetti, E. U.S. Patent No 9,102,703 B2. Publication date: 11/08/2015.