Diversity-oriented-synthesis of cyclic polyamines
Our team is interested in the asymmetric synthesis of cyclic polyamines. In particular, we focus our attention on the preparation of five- or six-membered rings containing 1,3-diamine motifs for the following reasons:
- Cyclic 1,3-diamines are found in a large amount of molecules possessing interesting biological activities, such as, for example, the ability to interfere with kinases, glycosidases, CNS receptors and various enzymes
- Differently substituted polyamines can be considered as versatile water-soluble building blocks for the design of active substances by a fragment-based approach
- Polyamines can serve as ligands for organometallic complexes.
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