Chemistry towards life sciences

+33 1 42 86 20 60, room T245

Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques (LCBPT) – CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Curriculum Vitae

2023 – Professeure (section 86) – Université Paris Cité

2011 – Habilitation à Diriger des Recherches : Approches ciblées pour la recherche de nouveaux agents antitumoraux, Université Paris Descartes

2010 – Maître de Conférences, Université Paris Descartes, LCBPT, UMR 8601

2004 – Maître de Conférences, Université Paris Descartes, INSERM U648, Pr C. Garbay

2003 – ATER, Université Paris Descartes, INSERM U648, Pr C. Garbay

2002 – ATER, Université de Nantes, UMR 6513, Equipe Pr D. Dubreuil

2001 – Stage post-doctoral, Université de Caen-Basse Normandie, Centre d’Etudes et de Recherche sur le Médicament de Normandie, Pr S. Rault

2000 – Thèse de Doctorat : 3-Azolylmethyleneindolin-2-ones, 3-imidazolylindoles et analogues structuraux à potentialité antitumorale, Pr G. LE BAUT, Faculté de Pharmacie – Université de Nantes.

Publications

• Halo-1,2,3-triazole: valuable compounds to access biologically relevant molecules, D. Coelho, Y. Colas, M. Etheve-Quelquejeu, E. Braud, L. Iannazzo, ChemBioChem 2024, doi.org/10.1002/cbic.202400150
• The catalytic mechanism of the RNA-methyltransferase METTL3, I. Corbeski, P. Andrés Vargas-Rosales, R. Kumar Bedi, J. Deng, D. Coelho, E. Braud, L. Iannazzo, Y. Li, D. Huang, M. Ethève-Quelquejeu, Q. Cui, A. Caflisch, eLife, 2023, doi.org/10.7554/eLife.92537.1
• Synthesis of Bisubstrate Analogues for RNA Methylation Studies using two Transition Metal-Catalyzed Reactions, D. Coelho, L. Le Corre, K. Bartosik, L. Iannazzo, E. Braud, M. Etheve-Quelquejeu, Chem. Eur. J. 2023, https://doi.org/10.1002/chem.202301134 
• Modulation of the Specificity of Carbapenems and Diazabicyclooctanes for Selective Activity against Mycobacterium tuberculosis, J.-P. Barnier, S. Saidjalolov, F. Bouchet, L.Mayer, Z. Edoo, I. Sayah, L. Iannazzo, M. Ethève-Quelquejeu, J.-L. Mainardi, E. Braud, M.Arthur Antimicrob. Agents Chemother. 2022, https://doi.org/10.1128/aac.02357-21
• Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase, V. Meynier, L. Iannazzo, M. Catala, S. Oerum, E. Braud, C. Atdjian, P. Barraud, M. Fonvielle, C. Tisné, M. Ethève-Quelquejeu Nucleic Acids Research, 2022, gkac354, https://doi.org/10.1093/nar/gkac354
• Click and Release Chemistry for Activity-based Purification of b-lactam targets, S. Saidjalolov, E. Braud, Z. Edoo, L. Iannazzo, F. Rusconi, M. Riomet, A. Sallustrau, F. Taran, M. Arthur,* M. Fonvielle*, M. Etheve-Quelquejeu*,  Chem. Eur. J., 2021, DOI:10.1002/chem.202100653. 
• Synthesis of carbapenems containing peptidoglycan-mimetics and inhibition of the cross-linking activity of a transpeptidase of the L,D specificity, S. Saidjalolov, Z. Edoo, M. Fonvielle, L. Mayer, L. Iannazzo, M. Arthur,* M. Etheve-Quelquejeu,* E. Braud*. Chem. Eur. J., 2021,doi.org/10.1002/chem.202004831. 
• Synthesis of triazole-linked SAM-adenosine conjugates: functionalization of adenosine at N1 or N6 position without protecting groups, C. Atdjian, D. Coelho, L. Iannazzo, M. Ethève-Quelquejeu, E. Braud, Molecules, 2020, 25, 3241, doi.org/10.3390/molecules25143241.
• “Design and Synthesis of a Peptide Derivative of Ametantrone Targeting the Major Groove of the d(GGCGCC)2 Palindromic Sequence”, A; Ongaro, G. Ribaudo, E. Braud, M. Etheve-Quelquejeu, M. De Franco, C. Garbay, L. Demange, N. Gresh, G. Zagotto, 2020, New Journal of Chemistry, doi:10.1039/C9NJ03817E 
• Oerum, S.; Catala, M.; Atdjian, C.; Brachet, F.; Ponchon, L.; Barraud, P.; Iannazzo, L.; Droogmans, L.; Braud, E.; Etheve-Quelquejeu, M.; Tisné C. Bisubstrate Analogues as Structural Tools to Investigate m(6)A Methyltransferase Active Sites. RNA Biol. 2019, 16 (6), 798–808. https://doi.org/10.1080/15476286.2019.1589360.

• C. Atdjian, L. Iannazzo, E. Braud, M. Ethève-Quelquejeu , Synthesis of SAM-adenosine conjugates for the study of m6A-RNA methyltransferases, Eur. J. Org. Chem , 2018, accepted.

• L. Iannazzo, M. Fonvielle, E. Braud, H. Hrebabecky, E. Prochazkova, R. Nencka, C. Mathé, M. Arthur, M. Etheve-Quelquejeu, Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes, Org. Biomol. Chem. , 2018, 16, 1903-1911.

• F. Ngadjeua, E. Braud, S. Saidjalolov, L. Iannazzo, D. Schnappinger, S. Ehrt, J-E. Hugonnet, D. Mengin-Lecreulx, D. Patin, M. Ethève-Quelquejeu, M. Fonvielle, M. Arthur,* Critical impact of peptidoglycan precursor amidation on the activity of L,D-transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis. Chem. Eur J., 2018, DOI : 10.1002/chem.201706082.

• M. Sarkis, M.A. Miteva, M. Chiara Dasso Lang, M. Jaouen, M-A. Sari, M-O. Galcéra, M. Ethève-Quelquejeu, C. Garbay, G. Bertho, E. Braud*, Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25, PROTEINS : Struct., Funct., Bioinf., 2017, 55, 13553-13557.

• M. Fonvielle, N. Sakkas, L. Iannazzo, C. Le Fournis, D. Patin, D. Mengin-Lecreulx, A. El-Sagheer, E. Braud, S. Cardon, T. Brown, M. Arthur*, M. Etheve-Quelquejeu*, Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes, Angewandte Chem., 2016, 55, 13553-13557.

• L. Le Corre, M. Chiara Dasso Lang, C. Garbay, C. Gravier-Pelletier, P. Busca, M.Ethève-Quelquejeu, E. Braud*, Synthesis of Multifunctionalized 2-Iminothiazolidin-4-ones and Their 2-Arylimino Derivatives” synthesis, Synthesis, 2016, 48(24) : 4569-4579.

• L. Iannazzo, D. Soroka, S. Triboulet, M. Fonvielle, F. Compain, V. Dubée, J-L. Mainardi, J-E. Hugonnet, E. Braud, M. Arthur*, M. Etheve-Quelquejeu*, Routes of synthesis of carbapenems for optimizing both the inactivation of L,D-transpeptidase LdtMt1 of Mycobacterium tuberculosis and the stability towards hydrolysis by β-lactamase BlaC, J. Med. Chem., 2016, DOI : 10.1021/acs.jmedchem.6b00096.

• L. Iannazzo, G. Laisné, M. Fonvielle, E. Braud, J-P. Herbeuval, M. Arthur*, M. Etheve-Quelquejeu*, Synthesis of 3’-Fluoro-tRNA Analogues to explore non-ribosomal peptide synthesis in bacteria, ChemBioChem, 2015, 16, 477-486.(VIP Paper, inside cover).

• M. Santarem, M. Fonvielle, N. Sakkas, G. Laisné, M. Chemama, J-P. Herbeuval, E. Braud, M. Arthur, M. Etheve-Quelquejeu*, Synthesis of 3’-triazoyl-dinucleotides as precursors of stable Phe-tRNAPhe and Leu-tRNALeu analogues, Bioorg. Med. Chem. Lett., 2014, 24, 3231 – 3233.

• D Mellal, M. Fonvielle, M. Santarem, M. Chemama, Y. Schneider, L. Iannazzo, E. Braud, M. Arthur, M. Etheve-Quelquejeu. Synthesis and biological evaluation of non-isomerizable analogues of Ala-tRNAAla. Org Biomol Chem, 2013, 11, 6161-6169.

• M. Sarkis, D.N. Tran, S. Kolb, M.A. Miteva, B.O. Villoutreix, C. Garbay, E. Braud*. Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors : effect of dimerisation on phosphatase inhibition. Bioorg Med Chem Lett, 2012, 22, 7345-7350.

• V. Lobjois, C. Froment, E. Braud, F. Grimal, O. Burlet-Schiltz, B. Ducommun, J.-P. Bouche. Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase. BiochemBiophysRes Commun, 2011, 410 (1), 87-90.

• T. Besset, E. Braud*, R. Jarray, C. Garbay, S. Kolb, P. M. Léo, C. Morin*. Preparation and evaluation of a set of bis-(methoxycarbonylmethylthio)-heteroquinones as CDC25B phosphatase inhibitors. Eur J Chem, 2011, 2(4), 433-440.

• S. Kolb, M.L. Goddard, A. Loukaci, O. Mondesert, B. Ducommun, E. Braud, C. Garbay. 5-Substituted [1]pyrindine derivatives with antiproliferative activity. Eur J Med Chem, 2010, 45, 896-901.

• S. Kolb, O. Mondesert, M.L. Goddard, D. Jullien, B.O. Villoutreix, B. Ducommun, C. Garbay, E. Braud*. Development of Novel Thiazolopyrimidines as CDC25B Phosphatase Inhibitors. ChemMedChem, 2009, 4, 633-648.