Laboratoire de Chimie et Biochimie
Pharmacologiques et Toxicologiques (LCBPT)
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06


Senior Engineer, CNRS

Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques (LCBPT) – CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06


2009 : PhD degree in Organic Chemistry – Paris Descartes University – Paris06

“Organic sulfur compounds bis-functionalized with two sulfurs in different oxidation states: synthesis and reactivity toward Zn(N2S2) complexes related to zinc finger motifs”

1998 : Advanced Master specialty Organic fine chemicals – ENSCM – Montpellier

1996 : Master degree in organic chemistry –  CPE and Lyon I University – Lyon

1994-95 : Licence / Master 1 in organic chemistry- Francois Rabelais University – Tours


Since 2017 : Research Engineer CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et toxicologiques, team : Chemistry, Biology, Modeling and Immunology for Therapy, Paris Descartes University

Since 2010 : Head of chemical library “Paris Descartes – UMR8601” available for physical and virtual screening, Paris Descartes University

Since 2005: health and safety manager of the laboratory, prevention assistant, Paris Descartes University

Jun 1999 – dec 2016: Engineer CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et toxicologiques, team : Metalloproteins, Pharmacochemistry and bioinorganic chemistry, Paris Descartes University

Fev – Sept 1998: Engineer, FOURNIER Laboratory, Dijon : Synthesis of therapeutic compounds for the regulation of blood fluidity.

Sept – jan 1997-98: Engineer-in-training, Laboratoire de chimie organique ESA 5076 ENSCM Montpellier: Synthesis of phosphorus compounds with strong uranium complexing capabilities to treat accidentally contaminated subjects.

Sept  – Jun 1995-96: Engineer-in-training, Laboratoire des matériaux organiques à propriétés spécifiques U.P.R 9031, Vernaison : Synthesis of phosphonic synthons for the elaboration of polymers with specific properties (membrane for hydrogen battery).

Main Research topics

CXCR4 modulators synthesis

Interferon molecular regulation during viral infection and autoimmune diseases: synthesis of small compounds able to modulate interferon production and development of fluorescent probes.

IFN modulators synthesis

Identification by screening of metabolites and xenobiotics interfering with IFN production in human peripheral blood mononuclear cells (PBMCs).

OCT modulators synthesis

Development of cyanines targeting low affinity / high capacity transporters as a therapeutic approach for depression.

Antimicrobial peptides synthesis

Syntheses of inhibitors and fluorescent probes specifically for metalloenzymes involved in bacterial growth to control the development of resistant strains.


  1. Hayek SPietrancosta N, Hovhannisyan A, Alves de Sousa R, Bekaddour N, Ermellino L, Tramontano E, Arnould S, Sardet C, Dairou J, Diaz O, Lotteau V, Nisole S, Melikyan G, Herbeuval JP, Vidalain PO. Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons bydenovopyrimidine biosynthesis inhibition, European Journal of Medicinal Chemistry 2019,   DOI: 10.1016/j.ejmech.2019.111855
  2. Orrico-Sanchez AChausset-Boissarie LAlves de Sousa RCoutens BRezai Amin SVialou VLouis FHessani ADansette PMZornoza TGruszczynski CGiros BGuiard BPAcher FPietrancosta NGautron S. Mol Psychiatry. 2019 Oct 16. Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression Molecular Psychiatry DOI: 10.1038/s41380-019-0548-4
  3. Iradyan M., Iradyan N, Hulin P, Hambardzumyan A, Gyulkhandanyan A, Alves de Sousa R, Hessani A, Roussakis C, Bollot G, Bauvais C7, Sakanyan V. Cancers 2019, 11(8), 1094. Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death. DOI: 10.3390/cancers11081094
  4. Hayek, S. ; Bekaddour, N. ; Besson L. ; Alves de Sousa, R. ; Pietrancosta, N. ; Viel, S.; Smith, N. ; Jacob, Y. ; Nisole, S.; Mandal, R.; Wishart, D. S.; Walzer, T.; Herbeuval, J.-P. and Vidalain, P.-O. SLAS Discovery (2019), 24(1), 25-37. Identification of Primary Natural Killer Cell Modulators by Chemical Library Screening with a Luciferase-Based Functional Assay. DOI: 10.1177/2472555218797078
  1. – Hambardzumyn A. A., Panosyan H. A., Tamazyan R. A., Ayvazyan A. G., Hovhannisyan G. Sh., Alves De Sousa R., Sakanyan V. A. N-, S-ALKYLATION OF 4-ALLYL-3-[2-(4-ALKOXYPHENYL)- QUINOLIN-4-YL]-4,5-DIHYDRO-1H-1,2,4-TRIAZOLE-5-THIONES WITH SUBSTITUTED BENZYLCHLORIDES. SYNTHESIS, DOCKING ANALYSIS AND СYTOTOXIC ACTIONChemical Journal of Armenia 2018
  2. – Laskaris PVicentefranqueira RHelynck OJouvion GCalera JAdu Merle LSuzenet FBuron F, Alves de Sousa RMansuy DCavaillon JMLatgé JPMunier-Lehmann HIbrahim-Granet OA novel polyaminocarboxylate compound to treat murine pulmonary aspergillosis by interfering with zinc metabolism. Antimicrob Agents Chemother. 2018 ;62(6). doi: 10.1128/AAC.02510-17
  3. Hayek S Pietrancosta NAlves de Sousa RBarouki RHerbeuval JPVidalain PO Pollution chimique et immunité innée antivirale : des liaisons dangereuses ?Virologie Vol 22, 1, 2018; DOI : 10.1684/vir.2018.0718
  1. Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria Scientific Reports 2017 DOI: 10.1038/s41598-017-00945-8
  2. New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E-aerogenes Gram-negative bacteria European Journal of Medicinal Chemistry 2017  DOI: 10.1016/j.ejmech.2016.10.054

  1. A unique peptide deformylase platform to rationally design and challenge novel active compounds Scientific Reports 2016 DOI: 10.1038/srep35429
  2. Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1 Scientific Reports 2016 DOI: 10.1038/srep21088

  1. New Peptides with Metal Binding Abilities and Their Use as Drug Carriers Bioconjugate Chemistry 2014 DOI: 10.1021/bc500317u
Journal of Antimicrobial Chemotherapy (2012), 67(6), 1392-1400
New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity
GOEMAERE, Emilie; MELET, Armelle; LARUE, Valery; LIEUTAUD, Aurelie; ALVES DE SOUSA, Rodolphe; CHEVALIER, Jacqueline; YIMGA-DJAPA, Liselotte; GIGLIONE, Carmela; HUGUET, Florian; ALIMI, Mickael; MEINNEL, Thierry; DARDEL, Frederic; ARTAUD, Isabelle; PAGES, Jean-Marie

ChemMedChem (2012), 7(6), 1020-1030.
Hydroxamic Acids as Potent Inhibitors of FeII and MnII E. coli Methionine Aminopeptidase: Biological Activities and X-ray Structures of Oxazole Hydroxamate-EcMetAP-Mn Complexes
HUGUET, Florian; MELET, Armelle; ALVES DE SOUSA, Rodolphe; LIEUTAUD, Aurelie; CHEVALIER, Jacqueline; MAIGRE, Laure; DESCHAMPS, Patrick; TOMAS, Alain; LEULLIOT, Nicolas; PAGES, Jean-Marie; ARTAUD, Isabelle

Tetrahedron (2008), 64(9), 2198-2206
Bis-β -sulfanylethylester and cyclic disulfide-S-oxides as precursors of bifunctionalized anionic derivatives with two oxidized sulfurs.
ALVES DE SOUSA, Rodolphe; ARTAUD, Isabelle.