Mélanie ETHEVE-QUELQUEJEU

Professor

Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques (LCBPT) – CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Curriculum Vitae

2012 – Professor of chemistry (section 32) – Université Paris Descartes

2009 – Habilitation à diriger des recherches, Université Pierre & marie Curie – ” Porphyrines, Carbohydrates and Nucleosides chemistry for synthesis of Biomolecules”.

2009 – Assistant Professor – Université Pierre et Marie Curie Paris VI – UMR 7201-IPCM – Team “Glycochimie Organique, Biologique et Supramoléculaire”, Pr. Matthieu Sollogoub

2000 – Assistant Professor – Université Pierre et Marie Curie Paris VI – UMR 7613, Team “Chimie des Glucides”, Pr. Jean-Marc Valéry

1998-99 – ATER-Université Pierre et Marie Curie Paris VI – UMR 7613, Team “Chimie des Glucides”, Pr. Jean-Marc Valéry

1998 – Post-Doctoral fellow -University of California, Santa Barbara, USA, Laboratoire du Pr. Bruce Lipshutz

1997- Post-Doctoral fellow- Stanford University, California, USA, Laboratoire du Pr. Jim Collman

1997 – Ph.D : “Etude de l’atropoisomérisation des tétrakis(o-nitrophényl) porphyrines et synthèses de modèles d’hémoproteines”.- Dr Eric Rose, Université Pierre et Marie Curie Paris VI

Publications

Vincent Meynier, Laura Iannazzo, Marjorie Catala, Stephanie Oerum, Emmanuelle Braud, Colette Atdjian, Pierre Barraud, Matthieu Fonvielle, Carine Tisné, Mélanie Ethève-Quelquejeu “Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase”,  Nucleic Acids Research, 2022 gkac354, https://doi.org/10.1093/nar/gkac354

Bouchet F.; Atze H.; Arthur M.; Etheve-Quelquejeu* M; Iannazzo* L., Traceless Staudinger ligation to introduce chemical diversity on β-lactamase inhibitors of second generation, Org. Lett., 2021, accepted. 

S. Saidjalolov, E. Braud, Z. Edoo, L. Iannazzo, F. Rusconi, M. Riomet, A. Sallustrau, F. Taran, M. Arthur,* M. Fonvielle*, M. Etheve-Quelquejeu*, Click and Release Chemistry for Activity-based Purification of b-lactam targets,   Chem. Eur. J., 2021, DOI:10.1002/chem.202100653. 

Rietmeyer, L.; Fix-boulier, N.; Le Fournis, C.; Iannazzo, L.; Kitoun, C.; Patin, D.; Mengin-lecreulx, D.; Etheve-Quelquejeu, M.; Arthur*, M.; Fonvielle*, M., Partition of tRNAGly isoacceptors between protein and cell-wall peptidoglycan synthesis in Staphylococcus aureus, Nucleic Acid Res. 2021, doi.org/10.1093/nar/gkaa1242.

S. Saidjalolov, Z. Edoo, M. Fonvielle, L. Mayer, L. Iannazzo, M. Arthur,* M. Etheve-Quelquejeu,* E. Braud*. Synthesis of carbapenems containing peptidoglycan-mimetics and inhibition of the cross-linking activity of a transpeptidase of the L,D specificity,  Chem. Eur. J., 2021, doi.org/10.1002/chem.202004831.

C. Kitoun, M. Fonvielle, F. Djago, N. Sakkas, M. Lefresne, Q. Blancart Remaury, P. Poinot, M. Arthur, M. Etheve-Quelquejeu, L. Iannazzo, Phosphine-Mediated Bioconjugation of 3’-end of RNA, Org. Lett., 2020, DOI:10.1021/acs.orglett.0c02982.

Li Bo; Li, Yongliang; Tomkiewicz-Raulet, C. ; Dao, P. ; Lietha, D.; Yen-Pon, E.; Du, Z.; Coumoul, X.;  Garbay, C.; Etheve-Quelquejeu, M.; Chen, H., Design, synthesis and biological evaluations of covalent inhibitors of Focal Adhesion Kinase (FAK) against human malignant glioblastoma, 2020, J. Med. Chem., Doi.org/10.1021/acs.jmedchem.0c01059.

C. Atdjian, D. Coelho, L. Iannazzo, M. Ethève-Quelquejeu, E. Braud, Synthesis of triazole-linked SAM-adenosine conjugates: functionalization of adenosine at N1 or N6 position without protecting groups, Molecules, 2020, 25, 3241, doi.org/10.3390/molecules25143241.

Y.Luo, Y. Xiao, D. Onidas, I. Kherbouche, S. Mahouche, T. Brulé, N. Félidj, L. Iannazzo, M. Ethève-Quelquejeu, F. Gazeau, C. Mangeney Raman Reporters Derived From Aryl Diazonium Salts for SERS Encoded-Nanoparticles2020Chem. Comm. doi.org/10.1039/D0CC02842H.

Flavie Bouchet, Heiner Atze, Matthieu Fonvielle, Zainab Edoo, Michel Arthur, Mélanie Ethève-Quelquejeu, Laura Iannazzo Diazabicyclooctane functionalization for inhibition of β-lactamases from enterobacteria, Journal of Medicinal Chemistry,  2020, 63, 10, 5257–5273  https://doi.org/10.1021/acs.jmedchem.9b02125

B. Mégarbane, Ca. Gamblin, O. Roussel1,  El. Bouaziz-Amar1, L. Chevillard, J. Callebert, H. Chen, G. Morineau, J-L. Laplanche, M. Etheve-Quelquejeu, M. E. Liechti, N. Benturquia, The neurobehavioral effects of the designer drug naphyrone – an experimental investigation with pharmacokinetics and concentration/effect relationship in mice, 2020, Psychopharmacology, https://doi.org/10.1007/s00213-020-05510-2.

Triboulet, S.; Edoo, Z.; Compain, F.; Ourghanlian, C.; Dupuis, A.; Dubee, V.; Sutterlin, L.; Atze, H.; Etheve-Quelquejeu, M.; Hugonnet, J.-E.; et al. Tryptophan Fluorescence Quenching in Beta-Lactam-Interacting Proteins Is Modulated by the Structure of Intermediates and Final Products of the Acylation Reaction. ACS Infect. Dis. 2019, 5 (7), 1169–1176. https://doi.org/10.1021/acsinfecdis.9b00023.

Oerum, S.; Catala, M.; Atdjian, C.; Brachet, F.; Ponchon, L.; Barraud, P.; Iannazzo, L.; Droogmans, L.; Braud, E.; Etheve-Quelquejeu, M.; et al. Bisubstrate Analogues as Structural Tools to Investigate m(6)A Methyltransferase Active Sites. RNA Biol. 2019, 16 (6), 798–808. https://doi.org/10.1080/15476286.2019.1589360.

Bhattacharje, N.; Triboulet, S.; Dubee, V.; Fonvielle, M.; Edoo, Z.; Hugonnet, J.-E.; Etheve-Quelquejeu, M.; Simorre, J.-P.; Field, M. J.; Arthur, M.; et al. Negative Impact of Carbapenem Methylation on the Reactivity of Beta-Lactams for Cysteine Acylation as Revealed by Quantum Calculations and Kinetic Analyses. Antimicrob. AGENTS Chemother. 2019, 63 (4). https://doi.org/10.1128/AAC.02039-18.

Benturquia, N.; Chevillard, L.; Poire, C.; Roussel, O.; Cohier, C.; Decleves, X.; Laplanche, J.-L.; Etheve-Quelquejeu, M.; Chen, H.; Megarbane, B. Is the 3,4-Methylendioxypyrovalerone/Mephedrone Combination Responsible for Enhanced Stimulant Effects? A Rat Study with Investigation of the Effect/Concentration Relationships. Psychopharmacology (Berl.) 2019, 236 (3), 891–901. https://doi.org/10.1007/s00213-018-4962-0.

Atehortua-Martinez, L. A.; Masniere, C.; Campolongo, P.; Chasseigneaux, S.; Callebert, J.; Zwergel, C.; Mai, A.; Laplanche, J.-L.; Chen, H.; Etheve-Quelquejeu, M.; et al. Acute and Chronic Neurobehavioral Effects of the Designer Drug and Bath Salt Constituent 3,4-Methylenedioxypyrovalerone in the Rat. J. Psychopharmacol. (Oxf.) 2019, 33 (3), 392–405. https://doi.org/10.1177/0269881118822151.

Yen-Pon, E.; Li, B.; Acebron-Garcia-de-Eulate, M.; Tomkiewicz-Raulet, C.; Dawson, J.; Lietha, D.; Frame, M. C.; Coumoul, X.; Garbay, C.; Etheve-Quelquejeu, M.; et al. Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. ACS Chem. Biol. 2018, 13 (8), 2067–2073. https://doi.org/10.1021/acschembio.8b00250.

Ngadjeua, F.; Braud, E.; Saidjalolov, S.; Iannazzo, L.; Schnappinger, D.; Ehrt, S.; Hugonnet, J.-E.; Mengin-Lecreulx, D.; Patin, D.; Etheve-Quelquejeu, M.; et al. Critical Impact of Peptidoglycan Precursor Amidation on the Activity of L,D-Transpeptidases from Enterococcus Faecium and Mycobacterium Tuberculosis. Chem.- Eur. J. 2018, 24 (22), 5743–5747. https://doi.org/10.1002/chem.201706082.

Iannazzo, L.; Fonvielle, M.; Braud, E.; Hrebabecky, H.; Prochazkova, E.; Nencka, R.; Mathe, C.; Arthur, M.; Etheve-Quelquejeu, M. Synthesis of TRNA Analogues Containing a Terminal Ribose Locked in the South Conformation to Study TRNA-Dependent Enzymes. Org. Biomol. Chem. 2018, 16 (11), 1903–1911. https://doi.org/10.1039/c8ob00019k.

Fonvielle, M.; Bouhss, A.; Hoareau, C.; Patin, D.; Mengin-Lecreulx, D.; Iannazzo, L.; Sakkas, N.; El Sagheer, A.; Brown, T.; Etheve-Quelquejeu, M.; et al. Synthesis of Lipid-Carbohydrate-Peptidyl-RNA Conjugates to Explore the Limits Imposed by the Substrate Specificity of Cell Wall Enzymes on the Acquisition of Drug Resistance. Chem.- Eur. J. 2018, 24 (56), 14911–14915. https://doi.org/10.1002/chem.201802360.

Edoo, Z.; Iannazzo, L.; Compain, F.; Gallay, I. L. de la S.; van Tilbeurgh, H.; Fonvielle, M.; Bouchet, F.; Le Run, E.; Mainardi, J.-L.; Arthur, M.; et al. Synthesis of Avibactam Derivatives and Activity on Beta-Lactamases and Peptidoglycan Biosynthesis Enzymes of Mycobacteria. Chem.- Eur. J. 2018, 24 (32), 8081–8086. https://doi.org/10.1002/chem.201800923.

Atdjian, C.; Iannazzo, L.; Braud, E.; Etheve-Quelquejeu, M. Synthesis of SAM-Adenosine Conjugates for the Study of m(6)A-RNA Methyltransferases. Eur. J. Org. Chem. 2018, No. 32, 4411–4425. https://doi.org/10.1002/ejoc.201800798.

Sarkis, M.; Miteva, M. A.; Lang, M. C. D.; Jaouen, M.; Sari, M.-A.; Galcera, M.-O.; Etheve-Quelquejeu, M.; Garbay, C.; Bertho, G.; Braud, E. Insights into the Interaction of High Potency Inhibitor IRC-083864 with Phosphatase CDC25. PROTEINS-Struct. Funct. Bioinforma. 2017, 85 (4), 593–601. https://doi.org/10.1002/prot.25236.

Dao, P.; Lietha, D.; Etheve-Quelquejeu, M.; Garbay, C.; Chen, H. Synthesis of Novel 1,2,4-Triazine Scaffold as FAK Inhibitors with Antitumor Activity. Bioorg. Med. Chem. Lett. 2017, 27 (8), 1727–1730. https://doi.org/10.1016/j.bmcl.2017.02.072.

(14)        Le Corre, L.; Lang, M. C. D.; Garbay, C.; Gravier-Pelletier, C.; Busca, P.; Etheve-Quelquejeu, M.; Braud, E. Synthesis of Multifunctionalized 2-Iminothiazolidin-4-Ones and Their 2-Arylimino Derivatives. Synth.-Stuttg. 2016, 48 (24), 4569–4579. https://doi.org/10.1055/s-0035-1562521.

Iannazzo, L.; Soroka, D.; Triboulet, S.; Fonvielle, M.; Compain, F.; Dubee, V.; Mainardi, J.-L.; Hugonnet, J.-E.; Braud, E.; Arthur, M.; et al. Routes of Synthesis of Carbapenems for Optimizing Both the Inactivation of L,D-Transpeptidase Ldt(Mt1) of Mycobacterium Tuberculosis and the Stability toward Hydrolysis by Beta-Lactamase BlaC. J. Med. Chem. 2016, 59 (7), 3427–3438. https://doi.org/10.1021/acs.jmedchem.6b00096.

Fonvielle, M.; Sakkas, N.; Iannazzo, L.; Le Fournis, C.; Patin, D.; Mengin-Lecreulx, D.; El-Sagheer, A.; Braud, E.; Cardon, S.; Brown, T.; et al. Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with TRNA-Binding Enzymes. Angew. Chem.-Int. Ed. 2016, 55 (43), 13553–13557. https://doi.org/10.1002/anie.201606843.

Smith, N.; Etheve-Quelquejeu, M.; Herbeuval, J.-P. Transformation of Plasmacytoid Dendritic Cells into Giant Multinuclear Cells by HIV-1. AIDS Res. Hum. RETROVIRUSES 2015, 31 (10), 959–960. https://doi.org/10.1089/aid.2015.0082.

annazzo, L.; Laisne, G.; Fonvielle, M.; Braud, E.; Herbeuval, J.-P.; Arthur, M.; Etheve-Quelquejeu, M. Synthesis of 3 `-Fluoro-TRNA Analogues for Exploring Non-Ribosomal Peptide Synthesis in Bacteria. CHEMBIOCHEM 2015, 16 (3), 477–486. https://doi.org/10.1002/cbic.201402523.

Iannazzo, L.; Benedetti, E.; Catala, M.; Etheve-Quelquejeu, M.; Tisne, C.; Micouin, L. Monitoring of Reversible Boronic Acid-Diol Interactions by Fluorine NMR Spectroscopy in Aqueous Media. Org. Biomol. Chem. 2015, 13 (33), 8817–8821. https://doi.org/10.1039/c5ob01362c.

Xu, B.; Unione, L.; Sardinha, J.; Wu, S.; Etheve-Quelquejeu, M.; Rauter, A. P.; Bleriot, Y.; Zhang, Y.; Martin-Santamaria, S.; Diaz, D.; et al. Gem-Difluorocarbadisaccharides: Restoring the Exo-Anomeric Effect. Angew. Chem.-Int. Ed. 2014, 53 (36), 9597–9602. https://doi.org/10.1002/anie.201405008.

Smith, N.; Etheve-Quelquejeu, M.; Herbeuval, J.-P. CD4 and Tumor Necrosis Factor-Related Apoptosis Ligand (TRAIL) Localization in HIV-Stimulated Plasmacytoid Dendritic Cells by Three-Dimensional Microscopy. AIDS Res. Hum. RETROVIRUSES 2014, 30 (12), 1158–1159. https://doi.org/10.1089/aid.2014.0125.

Santarem, M.; Fonvielle, M.; Sakkas, N.; Laisne, G.; Chemama, M.; Herbeuval, J.-P.; Braud, E.; Arthur, M.; Etheve-Quelquejeu, M. Synthesis of 3 `-Triazoyl-Dinucleotides as Precursors of Stable Phe-TRNA(Phe) and Leu-TRNA(Leu) Analogues. Bioorg. Med. Chem. Lett. 2014, 24 (15), 3231–3233. https://doi.org/10.1016/j.bmcl.2014.06.027.

Triboulet, S.; Dubee, V.; Lecoq, L.; Bougault, C.; Mainardi, J.-L.; Rice, L. B.; Etheve-Quelquejeu, M.; Gutmann, L.; Marie, A.; Dubost, L.; et al. Kinetic Features of L,D-Transpeptidase Inactivation Critical for Beta-Lactam Antibacterial Activity. PLOS ONE 2013, 8 (7). https://doi.org/10.1371/journal.pone.0067831.

Mellal, D.; Fonvielle, M.; Santarem, M.; Chemama, M.; Schneider, Y.; Iannazzo, L.; Braud, E.; Arthur, M.; Etheve-Quelquejeu, M. Synthesis and Biological Evaluation of Non-Isomerizable Analogues of Ala-TRNA(Ala). Org. Biomol. Chem. 2013, 11 (36), 6161–6169. https://doi.org/10.1039/c3ob41206g.

Leclerc, E.; Pannecoucke, X.; Etheve-Quelquejeu, M.; Sollogoub, M. Fluoro-C-Glycosides and Fluoro-Carbasugars, Hydrolytically Stable and Synthetically Challenging Glycomimetics. Chem. Soc. Rev. 2013, 42 (10), 4270–4283. https://doi.org/10.1039/c2cs35403a.

Fonvielle, M.; Mellal, D.; Patin, D.; Lecerf, M.; Blanot, D.; Bouhss, A.; Santarem, M.; Mengin-Lecreulx, D.; Sollogoub, M.; Arthur, M.; et al. Efficient Access to Peptidyl-RNA Conjugates for Picomolar Inhibition of Non-Ribosomal FemXWv Aminoacyl Transferase. Chem.- Eur. J. 2013, 19 (4), 1357–1363. https://doi.org/10.1002/chem.201201999.

Fonvielle, M.; de La Sierra-Gallay, I. L.; El-Sagheer, A. H.; Lecerf, M.; Patin, D.; Mellal, D.; Mayer, C.; Blanot, D.; Gale, N.; Brown, T.; et al. The Structure of FemX(Wv) in Complex with a Peptidyl-RNA Conjugate: Mechanism of Aminoacyl Transfer from Ala-TRNA(Ala) to Peptidoglycan Precursors. Angew. Chem.-Int. Ed. 2013, 52 (28), 7278–7281. https://doi.org/10.1002/anie.201301411.

Rose, E.; Raoul, N.; Etheve-Quelquejeu, M.; Gallo, E.; Boitrel, B.; Pecaut, J.; Dubois, L. Crystal Structure of a Chiral Binaphthyl Porphyrin. J. Porphyr. PHTHALOCYANINES 2012, 16 (3), 324–330. https://doi.org/10.1142/S1088424612500393.

Dubee, V.; Triboulet, S.; Mainardi, J.-L.; Etheve-Quelquejeu, M.; Gutmann, L.; Marie, A.; Dubost, L.; Hugonnet, J.-E.; Arthur, M. Inactivation of Mycobacterium Tuberculosis L,D-Transpeptidase Ldt(Mt1) by Carbapenems and Cephalosporins. Antimicrob. AGENTS Chemother. 2012, 56 (8), 4189–4195. https://doi.org/10.1128/AAC.00665-12.

Dubee, V.; Arthur, M.; Fief, H.; Triboulet, S.; Mainardi, J.-L.; Gutmann, L.; Sollogoub, M.; Rice, L. B.; Etheve-Quelquejeu, M.; Hugonnet, J.-E. Kinetic Analysis of Enterococcus Faecium L,D-Transpeptidase Inactivation by Carbapenems. Antimicrob. AGENTS Chemother. 2012, 56 (6), 3409–3412. https://doi.org/10.1128/AAC.06398-11.

Fonvielle, M.; Chemama, M.; Lecerf, M.; Villet, R.; Busca, P.; Bouhss, A.; Etheve-Quelquejeu, M.; Arthur, M. Decoding the Logic of the TRNA Regiospecificity of Nonribosomal FemX(Wv) Aminoacyl Transferase. Angew. Chem.-Int. Ed. 2010, 49 (30), 5115–5119. https://doi.org/10.1002/anie.201001473.

Fonvielle, M.; Chemama, M.; Villet, R.; Lecerf, M.; Bouhss, A.; Valery, J.-M.; Etheve-Quelquejeu, M.; Arthur, M. Aminoacyl-TRNA Recognition by the FemX(Wv) Transferase for Bacterial Cell Wall Synthesis. NUCLEIC ACIDS Res. 2009, 37 (5), 1589–1601. https://doi.org/10.1093/nar/gkn1039.

Chemama, M.; Fonvielle, M.; Arthur, M.; Valery, J.-M.; Etheve-Quelquejeu, M. Synthesis of Stable Aminoacyl-TRNA Analogues Containing Triazole as a Bioisoster of Esters. Chem.- Eur. J. 2009, 15 (8), 1929–1938. https://doi.org/10.1002/chem.200801563.

Chemama, M.; Fonvielle, M.; Villet, R.; Arthur, M.; Valery, J.-M.; Etheve-Quelquejeu, M. Stable Analogues of Aminoacyl-TRNA for Inhibition of an Essential Step of Bacterial Cell-Wall Synthesis (Vol 129, Pg 12642, 2007). J. Am. Chem. Soc. 2008, 130 (12), 4203. https://doi.org/10.1021/ja710232g.

Villet, R.; Fonvielle, M.; Busca, P.; Chemama, M.; Maillard, A. P.; Hugonnet, J.-E.; Dubost, L.; Marie, A.; Josseaume, N.; Mesnage, S.; et al. Idiosyncratic Features in TRNAs Participating in Bacterial Cell Wall Synthesis. NUCLEIC ACIDS Res. 2007, 35 (20), 6870–6883. https://doi.org/10.1093/nar/gkm778.

Etheve-Quelquejeu, M.; Tranchier, J.-P.; Rose-Munch, F.; Rose, E.; Naesens, L.; De Clercq, E. Eta(6)-(Arene)Tricarbonylehromium and Manganese Complexes Linked to 2 `-Deoxyuridine. ORGANOMETALLICS 2007, 26 (23), 5727–5730. https://doi.org/10.1021/om700674v.

Chemama, M.; Fonvielle, M.; Villet, R.; Arthur, M.; Valery, J.-M.; Etheve-Quelquejeu, M. Stable Analogues of Aminoacyl-TRNA for Inhibition of an Essential Step of Bacterial Cell-Wall Synthesis. J. Am. Chem. Soc. 2007, 129 (42), 12642+. https://doi.org/10.1021/ja0749946.