Publications
Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection. J Clin Immunol. 2021
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. Sci Immunol. 2021
Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths. Sci Immunol. 2021
From diagnosis to prognosis: Revisiting the meaning of muscle ISG15 overexpression in juvenile inflammatory myopathies Arthritis Rheumatol. 2020
Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: Dataset of 2,891 compounds, Data Brief 2020
Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: Efficacy of decitabine and valganciclovir alone or in combination, Antiviral Res 2020
Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine, Front Immunol 2020
Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors, Sci Rep 2020
et al, TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells, Sci Adv. 2019
Hayek S et al, Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition. Eur J Med Chem, 2019
Gitiauc C et al ,Inhibition of IFNa secretion in cells from patients with JDM under TBK1 treatment revealed by Single Molecular Assay technology . Rheumatology, 2019
Melki I et al, Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defined by differentially enhanced interferon-α signalling. Rheumatology , 2019
Melki I, Devilliers H, Gitiaux C, Bondet V, Belot A, Bodemer C, et al. Circulating interferon-α measured with a highly sensitive assay as a biomarker for juvenile inflammatory myositis activity. Arthritis Rheumatol. 2019 Sep 5;
Choi SG, Olivet J, Cassonnet P, Vidalain P-O, Luck K, Lambourne L, et al. Maximizing binary interactome mapping with a minimal number of assays. Nat Commun. 2019 Aug 29;10(1):3907.
Iradyan M, Iradyan N, Hulin P, Hambardzumyan A, Gyulkhandanyan A, Alves de Sousa R, et al. Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death. Cancers (Basel). 2019 Aug 1;11(8).
Smith N, Rodero MP, Bekaddour N, Bondet V, Ruiz-Blanco YB, Harms M, et al. Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment. Sci Adv. 2019 Jul 10;5(7):eaav9019.
Thieulent CJ, Hue ES, Fortier CI, Dallemagne P, Zientara S, Munier-Lehmann H, et al. Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay. Virology. 2019 Jan 2;526:105–116.
Hayek S, Bekaddour N, Besson L, Alves de Sousa R, Pietrancosta N, Viel S, et al. Identification of Primary Natural Killer Cell Modulators by Chemical Library Screening with a Luciferase-Based Functional Assay. SLAS Discov. 2019 Jan;24(1):25–37.
Tavernier Q, Bennana E, Poindessous V, Schaeffer C, Rampoldi L, Pietrancosta N, et al. Regulation of IRE1 RNase activity by the Ribonuclease inhibitor 1 (RNH1). Cell Cycle. 2018 Sep 5;17(15):1901–1916.
Müller JA, Harms M, Krüger F, Groß R, Joas S, Hayn M, et al. Semen inhibits Zika virus infection of cells and tissues from the anogenital region. Nat Commun. 2018 Jun 7;9(1):2207.
Fer MJ, Corre LL, Pietrancosta N, Evrard-Todeschi N, Olatunji S, Bouhss A, et al. Bacterial Transferase MraY, a Source of Inspiration towards New Antibiotics. Curr Med Chem. 2018;25(42):6013–6029.
Durand CM, Dhers L, Tesson C, Tessa A, Fouillen L, Jacqueré S, et al. CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56. Hum Mutat. 2018;39(1):140–151.
Smith N, Pietrancosta N, Herbeuval J-P. [CXCR4, master regulator of innate immune responses?]. Med Sci (Paris). 2017 Sep 18;33(8-9):711–713.
Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, et al. Original chemical series of pyrimidine biosynthesis inhibitors that boost the antiviral interferon response. Antimicrob Agents Chemother. 2017 Sep 22;61(10).
Ducassou L, Dhers L, Jonasson G, Pietrancosta N, Boucher J-L, Mansuy D, et al. Membrane-bound human orphan cytochrome P450 2U1: Sequence singularities, construction of a full 3D model, and substrate docking. Biochimie. 2017 Sep;140:166–175.
Fettelschoss V, Burda P, Sagné C, Coelho D, De Laet C, Lutz S, et al. Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B12-trafficking proteins ABCD4 and LMBD1. J Biol Chem. 2017 Jul 14;292(28):11980–11991.
Khiar S, Lucas-Hourani M, Nisole S, Smith N, Helynck O, Bourgine M, et al. Identification of a small molecule that primes the type I interferon response to cytosolic DNA. Sci Rep. 2017 May 31;7(1):2561.
Smith N, Pietrancosta N, Davidson S, Dutrieux J, Chauveau L, Cutolo P, et al. Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat Commun. 2017 Feb 9;8:14253.
Müller JA, Harms M, Schubert A, Mayer B, Jansen S, Herbeuval J-P, et al. Development of a high-throughput colorimetric Zika virus infection assay. Med Microbiol Immunol. 2017 Apr;206(2):175–185.
Smith N, Vidalain P-O, Nisole S, Herbeuval J-P. An efficient method for gene silencing in human primary plasmacytoid dendritic cells: silencing of the TLR7/IRF-7 pathway as a proof of concept. Sci Rep. 2016 Jul 14;6:29891.
Saïdi H, Bras M, Formaglio P, et al. HMGB1 Is Involved in IFN-α Production and TRAIL Expression by HIV-1-Exposed Plasmacytoid Dendritic Cells: Impact of the Crosstalk with NK Cells. PLoS Pathog 2016; 12: e1005407.
Smith N, Herbeuval J-P. [Plasmacytoid dendritic cells: the novel Eldorado for antiviral therapy?]. Biol Aujourdhui 2015; 209: 135–144.
Smith N, Etheve-Quelquejeu M, Herbeuval J-P. Transformation of Plasmacytoid Dendritic Cells into Giant Multinuclear Cells by HIV-1. AIDS Res Hum Retroviruses 2015; 31: 959–960.
Dao P, Smith N, Scott-Algara D, Garbay C, Herbeuval JP, Chen H. Restoration of TRAIL-induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor, PH11. Cancer Lett 2015; 360: 48–59.
Iannazzo L, Laisné G, Fonvielle M, et al. Synthesis of 3’-fluoro-tRNA analogues for exploring non-ribosomal peptide synthesis in bacteria. Chembiochem 2015; 16: 477–486.
Smith N, Etheve-Quelquejeu M, Herbeuval J-P. CD4 and Tumor Necrosis Factor-Related Apoptosis Ligand (TRAIL) localization in HIV-stimulated plasmacytoid dendritic cells by three-dimensional microscopy. AIDS Res Hum Retroviruses 2014; 30: 1158–1159.
Dao P, Smith N, Tomkiewicz-Raulet C, et al. Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity. J Med Chem 2015; 58: 237–251.
Santarem M, Fonvielle M, Sakkas N, et al. Synthesis of 3’-triazoyl-dinucleotides as precursors of stable Phe-tRNA(Phe) and Leu-tRNA(Leu) analogues. Bioorg Med Chem Lett 2014; 24: 3231–3233.
Dao P, Jarray R, Smith N, et al. Inhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activities. Cancer Lett 2014; 348: 88–99.