Laura IANNAZZO
Research Scientist, CNRS
Chemistry towards life sciences
Laboratoire de Chimie et Biochimie
Pharmacologiques et Toxicologiques (LCBPT)
CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France
Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques (LCBPT) – CNRS UMR 8601
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France
Curriculum Vitae
2021: Habilitation à diriger des recherches, Université de Paris
Depuis 2016 : Chargé de Recherche CNRS, UMR 8601, Université Paris Descartes.
2014-2016 : POST-DOCTORAT UMR 8601,Université Paris Descartes. (Pr Mélanie Ethève-Quelquejeu).
2013-2014 : ATER, UMR 8601 Université Paris Descartes. (Dr Laurent Micouin).
2012-2013 : ATER, UMR 8601, Université Paris Descartes. (Pr Mélanie Ethève-Quelquejeu).
2010-2011 : POST-DOCTORAT University of Pennsylvania, Philadelphia (USA). (Pr Gary. A. Molander).
2007-2010 : DOCTORAT Université Pierre et Marie Curie. (Dr Corinne Aubert et du Pr Max Malacria). Réactivité de nouveaux partenaires insaturés dans des réactions de Cycloadditions [2+2+2] catalysées par des complexes du cobalt.
2006-2007 : MASTER CHIMIE Université Pierre et Marie Curie.
Thème de recherche
Synthèse organique – Nucléosides, Nucléotides et ARN – Chimie medicinal : carbapénèmes modifiés – Interface Chimie/Biologie
Publications
Copper catalyzed cycloaddition for the synthesis of non isomerisable 2′ and 3′-regioisomers of arg-tRNAarg, Y.Afandizada, T.Abeywansha, V.Guerineau , Y.Zhang, B. Sargueil, L. Ponchon*, L. Iannazzo*, M. Etheve-Quelquejeu*, Methods, 2024, 229, 94-107
Halo-1,2,3-triazole: valuable compounds to access biologically relevant molecules, D. Coelho, Y. Colas, M. Etheve-Quelquejeu, E. Braud, L. Iannazzo, ChemBioChem 2024, doi.org/10.1002/cbic.202400150
The catalytic mechanism of the RNA-methyltransferase METTL3, I. Corbeski, P. Andrés Vargas-Rosales, R. Kumar Bedi, J. Deng, D. Coelho, E. Braud, L. Iannazzo, Y. Li, D. Huang, M. Ethève-Quelquejeu, Q. Cui, A. Caflisch, eLife, 2023,doi.org/10.7554/eLife.92537.1
Synthesis of Bisubstrate Analogues for RNA Methylation Studies using two Transition Metal-Catalyzed Reactions, D. Coelho, L. Le Corre, K. Bartosik, L. Iannazzo, E. Braud, M. Etheve-Quelquejeu, Eur. J. 2023, https://doi.org/10.1002/chem.202301134
Ruthenium-Catalyzed Cycloaddition for Introducing Chemical Diversity in Second Generation β-Lactamase Inhibitors, F. Bouchet, J-P. Barnier, I. Sayah, Y. Bagdad, M.A. Miteva, M. Arthur, M. Ethève-Quelquejeu, L. Iannazzo, ChemMedChem, 2023, https://doi.org/10.1002/cmdc.202300077
Traceless Staudinger Ligation to Access to Stable Aminoacyl- or Peptidyl-dinucleotides, C. Kitoun, S. Saidjalolov, D. Bouquet, F. Djago, Q. Blancart Remaury, B. Sargueil, P. Poinot, Pauline; M. Etheve-Quelquejeu, L. Iannazzo, ACS Omega, 2022, accepted.
Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis, Rietmeyer, L.; Li de la Sierra-Gallay, I.; Schepers, G.; Dorchêne, D.; Iannazzo, L.; Patin, D.; Touzé, T.; van Tilbeurgh, H.; Herdewijn, P.; Etheve-Quelquejeu, M.; Fonvielle, M., Nucleic Acids Research, 2022, Accepted
Modulation of the Specificity of Carbapenems and Diazabicyclooctanes for Selective Activity against Mycobacterium tuberculosis, Jean-Philippe Barnier, Saidbakhrom Saidjalolov, Flavie Bouchet, Louis Mayer, Zainab Edoo, Inès Sayah, Laura Iannazzo, Mélanie Ethève-Quelquejeu, Jean-Luc Mainardi, Emmanuelle Braud, Michel Arthur Antimicrob. Agents Chemother. 2022, https://doi.org/10.1128/aac.02357-21
Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase, Vincent Meynier, Laura Iannazzo, Marjorie Catala, Stephanie Oerum, Emmanuelle Braud, Colette Atdjian, Pierre Barraud, Matthieu Fonvielle, Carine Tisné, Mélanie Ethève-Quelquejeu Nucleic Acids Research, 2022, gkac354, https://doi.org/10.1093/nar/gkac354
Traceless Staudinger ligation to introduce chemical diversity on β-lactamase inhibitors of second generation, Bouchet F.; Atze H.; Arthur M.; Etheve-Quelquejeu* M; Iannazzo* L., Org. Lett., 2021, accepted.
Click and Release Chemistry for Activity-based Purification of b-lactam targets, S. Saidjalolov, E. Braud, Z. Edoo, L. Iannazzo, F. Rusconi, M. Riomet, A. Sallustrau, F. Taran, M. Arthur, M. Fonvielle, M. Etheve-Quelquejeu, Chem. Eur. J., 2021, DOI:10.1002/chem.202100653.
Partition of tRNAGly isoacceptors between protein and cell-wall peptidoglycan synthesis in Staphylococcus aureus, Rietmeyer, L.; Fix-boulier, N.; Le Fournis, C.; Iannazzo, L.; Kitoun, C.; Patin, D.; Mengin-lecreulx, D.; Etheve-Quelquejeu, M.; Arthur*, M.; Fonvielle*, M., Nucleic Acid Res. 2021, doi.org/10.1093/nar/gkaa1242..
Synthesis of carbapenems containing peptidoglycan-mimetics and inhibition of the cross-linking activity of a transpeptidase of the L,D specificity, S. Saidjalolov, Z. Edoo, M. Fonvielle, L. Mayer, L. Iannazzo, M. Arthur,* M. Etheve-Quelquejeu,* E. Braud*, Chem. Eur. J., 2021, doi.org/10.1002/chem.202004831.
Phosphine-Mediated Bioconjugation of 3’-end of RNA, C. Kitoun, M. Fonvielle, F. Djago, N. Sakkas, M. Lefresne, Q. Blancart Remaury, P. Poinot, M. Arthur, M. Etheve-Quelquejeu, L. Iannazzo, Org. Lett. 2020, DOI:10.1021/acs.orglett.0c02982.
Synthesis of triazole-linked SAM-adenosine conjugates: functionalization of adenosine at N1 or N6 position without protecting groups, C. Atdjian, D. Coelho, L. Iannazzo, M. Ethève-Quelquejeu, E. Braud, Molecules, 2020, 25, 3241. doi.org/10.3390/molecules25143241.
Raman Reporters Derived From Aryl Diazonium Salts for SERS Encoded-Nanoparticles, Y. Luo, Y. Xiao, D. Onidas, L. Iannazzo, M. Etheve-Quelquejeu, A. Lamouri, N. Felidj, S. Mahouche, T. Brule, N. Gagey-Eilstein, F. Gazeau, C. Mangeney, Chem. Commun. 2020, 56, 6822-6825. doi.org/10.1039/D0CC02842H.
Diazabicyclooctane functionalization for inhibition of β-lactamases from enterobacteria, Flavie Bouchet, Heiner Atze, Matthieu Fonvielle, Zainab Edoo, Michel Arthur, Mélanie Ethève-Quelquejeu, Laura Iannazzo Journal of Medicinal Chemistry, 2020, 63, 10, 5257–5273. https://doi.org/10.1021/acs.jmedchem.9b02125
Bisubstrate Analogues as Structural Tools to Investigate m(6)A Methyltransferase Active Sites, Oerum, S.; Catala, M.; Atdjian, C.; Brachet, F.; Ponchon, L.; Barraud, P.; Iannazzo, L.; Droogmans, L.; Braud, E.; Etheve-Quelquejeu, M.; Tisné C. . RNA Biol. 2019, 16 (6), 798–808. https://doi.org/10.1080/15476286.2019.1589360
Synthesis of lipid-carbohydrate-peptidyl-RNA conjugates to explore the limits imposed by the substrate specificity of cell wall enzymes on the acquisition of drug resistance , Fonvielle M., Bouhss A., Hoareau C., Patin D., Mengin-Lecreulx D., Iannazzo L., Sakkas N., El Sagheer A., Brown T., Ethève-Quelquejeu M., Arthur M. Chem. Eur. J. , 2018, x, doi.org/10.1002/chem.201802360
Synthesis of SAM-adenosine conjugates for the study of m6A-RNA methyltransferases , C. Atdjian, L. Iannazzo, E. Braud, M. Ethève-Quelquejeu Eur. J. Org. Chem , 2018, x, doi.org/10.1002/ejoc.201800798.
Synthesis of avibactam derivatives and activity on β-lactamases and peptidoglycan biosynthesis enzymes of mycobacteria , Z. Edoo, L. Iannazzo, F. Compain, H. van Tilbeurgh, I. Li dela Sierra Galay, M. Fonvielle, M. Arthur, M. Ethève-Quelquejeu, and J-E. Hugonnet, Chem. Eur. J., 2018, x, 24, 8081-80-86.
Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes , L. Iannazzo, M. Fonvielle, E. Braud, H. Hrebabecky, E. Prochazkova, R. Nencka, C. Mathé, M. Arthur, M. Etheve-Quelquejeu, Org. Biomol. Chem., 2018, 16, 1903-1911.
Critical impact of peptidoglycan precursor amidation on the activity of L,D-transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis , F. Ngadjeua, E. Braud, S. Saidjalolov, L. Iannazzo, D. Schnappinger, S. Ehrt, J-E. Hugonnet, D. Mengin-Lecreulx, D. Patin, M. Ethève-Quelquejeu, M. Fonvielle, M. Arthur, Chem. Eur. J., 2018, xx, DOI : 10.1002/chem.201706082.
Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes, M. Fonvielle, N. Sakkas, L. Iannazzo, C. LeFournis, D. Patin, D. Mengin-Lecreulx, A. El-Sagheer, E. Braud, S. Cardon, T. Brown, M. Arthur, M. Etheve-Quelquejeu, Angew. Chem. Int. Ed, 2016, 55, 13553-13557.
Routes of synthesis of carbapenems for optimizing both the inactivation of L,D-transpeptidase LdtMt1 of Mycobacterium tuberculosis and the stability towards hydrolysis by β-lactamase BlaC, L.Iannazzo, D. Soroka, S. Triboulet, M. Fonvielle, F., Compain, V. Dubée, J. L. Mainardi, J. E. Hugonnet, E. Braud, M. Arthur, M. Etheve-Quelquejeu, J. Med. Chem. 2016, 59, 3427-3438.
Monitoring of reversible boronic acid-diol interactions by fluorine NMR spectroscopy in aqueous media, L. Iannazzo, E. Benedetti, M. Catala, M. Etheve-Quelquejeu, C. Tisné, L. Micouin, Org. Biomol.Chem. 2015, 13, 8817-8821.
Synthesis of 3’-Fluoro-tRNA Analogues to explore non-ribosomal peptide synthesis in bacteria, L. Iannazzo, G. Laisné, M. Fonvielle, E.Braud, J.-P. Herbeuval,M. Arthur, M.Etheve-Quelquejeu, ChemBioChem. 2015, 16, 477-486, Very Important Paper. Inside cover
Synthesis and biologicalevaluation of non-isomeizable analogues of Ala-tRNAla.
D. Mellal, M. Fonvielle, M. Santarem, M. Chemama, Y. Schneider, L. Iannazzo, E. Braud, M. Arthur, M. Etheve-Quelquejeu, Org. Biomol. Chem. 2013, 11, 6161-6169. Hot Article.
Activation of Si-Si Bonds for Copper(I)-Catalyzed Conjugate Silylation.
L. Iannazzo, G. A. Molander, Eur. J. Org. Chem. 2012, 26, 4923-4926.
Palladium-Catalyzed Hiyama Cross-Coupling of Aryltrifluorosilanes with Aryl and Heteroaryl Chlorides.
G. A. Molander, L. Iannazzo, J. Org. Chem. 2011, 76, 9182-9187.
Co(I)- versus Ru(I)-Catalyzed [2+2+2] Cycloadditions Involving Alkynyl Halides.
L. Iannazzo, N. Kotera, M. Malacria, C. Aubert, V. Gandon, J. Organomet. Chem. 2011, 696, 3906-3908.
Alkynylboronates and -Boramides in Co(I)- and Rh(I)-Catalyzed [2+2+2] Cycloadditions : Construction of Oligoaryls by Selective Suzuki Couplings.
L. Iannazzo, K. P. C. Vollhardt, M. Malacria, C. Aubert, V. Gandon, Eur. J. Org. Chem. 2011, 18, 3283-3292. Cover picture
Cobalt-Mediated Linear 2:1 Co-oligomerization of Alkynes with Enol Ethers to Give 1-Alkoxy-1,3,5-Trienes : A Missing Mode of Reactivity.
D. Leboeuf, L. Iannazzo, A. Geny, K. P. C. Vollhardt, M. Malacria, C. Aubert, V. Gandon, Chem. Eur. J. 2010, 16, 8904-8913.
Air stable (C5H5)Co catalysts for [2+2+2] cycloadditions.
A. Geny, N. Agenet, L. Iannazzo, M. Malacria, C. Aubert, V. Gandon, Angew. Chem. Int. Ed, 2009, 48, 1810-1813.