Chemical Biology, Immunology

+33 1 76 53 42 36, room R177

Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques (LCBPT) – CNRS UMR 8601 Université Paris Descartes 45 Rue des Saints Pères 75270 Paris Cedex 06 France

Curriculum Vitae

Publications

1/ Selvam, C., Lemasson, I. A., Brabet, I., Oueslati, N., Karaman, B., Cabaye, A., Tora, A. S., Commare, B., Courtiol, T., Cesarini, S., McCort-Tranchepain, I., Rigault, D., Mony, L., Bessiron, T., McLean, H., Leroux, F. R., Colobert, F., Daniel, H. Goupil-Lamy, A., Bertrand, H.-O., Goudet, C., Pin, J.-P. and Acher, F. C. Increased potency and selectivity for group-III metabotropic glutamate receptor agonists binding at dual sites. J Med Chem 2018, 61, 1969-1989.  https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01438

2/ Tassin, V.; Girard, B.; Chotte ,A.; Fontanaud, P.; Rigault, D.; Kalinichev, M.; Perroy, J.; Acher, F.; Fagni, L. and Bertaso, F. Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network. Frontiers in neural circuits 2016, 31, article number 31. https://www.frontiersin.org/articles/10.3389/fncir.2016.00031/full

3/ Commare, Bruno; Rigault, Delphine; Lemasson, Isabelle A.; Deschamps, Patrick; Tomas, Alain; Roussel, Pascal; Brabet, Isabelle; Goudet, Cyril; Pin, Jean-Philippe; Leroux, Frederic R.; et al. Determination of the absolute configuration of phosphinic analogues of glutamate. From Organic & Biomolecular Chemistry (2015),  13(4), 1106-1112. https://pubs.rsc.org/en/content/articlepdf/2015/ob/c4ob01960a

4/ Jalan-Sakrikar, Nidhi; Field, Julie R.; Klar, Rebecca; Mattmann, Margrith E.; Gregory, Karen J.; Zamorano, Rocio; Engers, Darren W.; Bollinger, Sean R.; Weaver, C. David; Days, Emily L.; Lewis, L. Michelle; Utley, Thomas J.; Hurtado, Miguel; Rigault, Delphine; Acher, Francine; Walker, Adam G.; Melancon, Bruce J.; Wood, Michael R.; Lindsley, Craig W.; Conn, P. Jeffrey; Xiang, Zixiu; Hopkins, Corey R.; Niswender, Colleen M.  Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7. ACS Chem Neurosci. 2014 Dec 17; 5(12): 1221–1237. https://pubs.acs.org/doi/10.1021/cn500153z

5/ Acher, Francine; Pin, Jean-Philippe; Goudet, Cyril; Eschalier, Alain; Busserolles, Jerome; Rigault, Delphine; Lemasson, Isabelle; Cesarini, Sara; Commare, Bruno
Assignee: Universite Paris Descartes, Fr.; Centre National de la Recherche Scientifique (CNRS); Universite d’Auvergne
Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof. PCT Int. Appl. (2012), WO 2012156931 A1 20121122.

7/ Selvam, Chelliah; Oueslati, Nadia; Lemasson, Isabelle A.; Brabet, Isabelle; Rigault, Delphine; Courtiol, Tiphanie; Cesarini, Sara; Triballeau, Nicolas; Bertrand, Hugues-Olivier; Goudet, Cyril; Pin, Jean-Philippe; Acher, Francine C. A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists. Journal of Medicinal Chemistry  (2010),  53(7),  2797-2813. https://pubs.acs.org/doi/pdf/10.1021/jm901523t

8/ Lemasson, Isabelle A.; Selvam, Chelliah; Oueslati, Nadia; Brabet, Isabelle; Courtiol, Tiphanie; Rigault, Delphine; Goudet, Cyril; Amalric, Marianne; Bertrand, Hugues-Olivier; Pin, Jean-Philippe; et al. Is metabotropic glutamate receptor mGlu4R a good target to treat Parkinson’s disease symptoms? Design and evaluation of potent and selective agonists Abstracts of Papers, 238th ACS National Meeting, Washington, DC, United States, August 16-20, 2009 (2009), MEDI-088.