PhD Students
Thomas Moreau
Margaux Cescato
Diego Bletry

Scientific projects and goals:

• Research Projects

  Pathophysiology of juvenile dermatomyositis.

  Juvenile dermatomyositis is a rare auto immune disease of unknown origin characterized by sustained overproduction of type I interferons. We are more specifically interested in the mechanisms responsible for this type I interferon overproduction/signature, and its impact on disease progression and severity. In line with this questioning, we are involved in clinical trials evaluating the benefit of inhibitors of interferon signalling in these patients.

  Genotype / phenotype association in genetic auto-inflammatory diseases.

  Numerous genes have been associated with inflammatory diseases. Interestingly, mutations in distinct domains of a same protein can be associated with distinct diseases, or variable manifestation of a same disease. We are interested in the molecular and cellular alterations resulting from mutations in different domains of a same protein, and its association with clinical features.

  Pathophysiology of adult idiopathic inflammatory and autoimmune diseases.

  The pathophysiology of most non-genetic inflammatory and autoimmune diseases is still poorly understood. We aim to identify deregulations of specific pathways within professional immune cells in patients suffering from idiopathic inflammatory or autoimmune diseases. This work should provide new insights into the mechanisms leading to the onset of the diseases and help identify new therapeutic targets or markers that predict the response to treatments

Main collaborators:

Dr Brigitte Bader Meunier – Necker Hospital
Dr Benjamin Chaigne – Cochin Hospital
Dr Julien Dairou – UMR8601
Dr Darragh Duffy – Pasteur Institut
Pr Sophie Georgin-Lavialle – Tenon Hospital
Dr Laurent Le Corre – UMR8601
Dr Isabelle Melki – Robert Debré Hospital
Dr Nicolas Michalski – Institut de L’audition / Pasteur Institut
Pr Pierre Quartier – Necker Hospital
Pr Angèle Soria – Tenon Hospital

Main Publications

Le Voyer T et al, JAK inhibitors are effective in a subset of patients with juvenile dermatomyositis: a monocentric retrospective study. Rheumatology 2021.