Recent Publications

Mar 6, 2022 | Publications

Mai 2022

1) V. Meynier, L. Iannazzo, M. Catala, S. Oerum, E. Braud, C.Atdjian, P. Barraud, M. Fonvielle, C. Tisné, M.Ethève-Quelquejeu “Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase” Nucleic Acids Research, 2022, 50, (10), 5793–5806. DOI: https://doi.org/10.1093/nar/gkac354

Mars 2022

1) M. Oliver, L, Le Corre, M. Poinsot, M, Bosco, H. Wan, A. Amoroso, B. Joris, A. Bouhss, S. Calvet-Vitale, C. Gravier-Pelletier “A Sub-Micromolar MraYAA Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling” Molecules 2022, 27(6), 1769. DOI:  https://doi.org/10.3390/molecules27061769

Janaury 2022
  1. D. R. Boyd, N. D. Sharma, P. J. Stevenson, P. Hoering, C. C. R. Allen, P. M. Dansette “Monooxygenase- and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation”. Int J Mol Sci. 2022, 23(2) 909. DOI:https://doi.org/10.3390/ijms23020909
December 2021
  1. S. Felder, M.-L. Delcourt, M.H.E. Bousquet, D.  Jacquemin, R. Rodríguez, L. Favereau, J. Crassous, L. Micouin, E. Benedetti “Planar chiral analogues of PRODAN based on a [2.2]paracyclophane scaffold: Synthesis and photophysical studies”. J. Org. Chem. 2021, just accepted
  2. G. Kirby, L. Grimaud, M. R. Vitale,  G. Prestat, F. Berhal “Iron(ii)-catalyzed intermolecular aziridination of alkenes employing hydroxylamine derivatives as clean nitrene sources” Green Chem., 2021,23, 9428-9432. https://doi.org/10.1039/D1GC03495B
  3. G. De Leener, D. Over, O. Reinaud, I. Jabin “Turning on anion and betaine hosting by a small structural change of a biomimetic cavity: a case study” Supramol. Chem. 2021, DOI: 10.1080/10610278.2021.2011890
  4. Bitam, S.; Elbahnsi, A.; Creste, G.; Pranke, I.; Chevalier, B.; Berhal, F.; Hoffmann, B.; Servel, N.; Tondelier, D.; Hatton, A.; Moquereau, C.; Faria Da Cunha, M.; Pastor, A.; Lepissier, A.; Hinzpeter, A.; Mornon, J.-P.; Prestat, G.; Edelman, A.; Callebaut, I.; Gravier-Pelletier, C.; Sermet-Gaudelus, I. “New Insights into Structure and Function of Bis-Phosphinic Acid Derivatives and Implications for CFTR Modulation.” Sci Rep 2021, 11, 6842.
    DOI: https://doi.org/10.1038/s41598-021-83240-x
  5. Bardin, E.; Pastor, A.; Semeraro, M.; Golec, A.; Hayes, K.; Chevalier, B.; Berhal, F.; Prestat, G.; Hinzpeter, A.; Gravier-Pelletier, C.; Pranke, I.; Sermet-Gaudelus, I. “Modulators of CFTR. Updates on Clinical Development and Future Directions.” Eur. J. Med. Chem. 2021, 113195  DOI: doi.org/10.1016/j.ejmech.2021.113195
  6. Oliver, M.; Le Corre, L.; Poinsot, M.; Corio, A.; Madegard, L.; Bosco, M.; Amoroso, A.; Joris, B.; Auger, R.; Touzé, T.; Bouhss, A.; Calvet-Vitale, S.; Gravier-Pelletier, C.“Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors.”  Org. Biomol. Chem. 2021, 19(26), 5844-5866, DOI: 10.1039/D1OB00710F.
  7. Pujol C, Legrand A, Parodi L, Boucher, J.-L.; Le Corre, L. et al. “Implication of folate deficiency in CYP2U1 loss of function.” J Exp Med. 2021; 218(11):e20210846. doi: 10.1084/jem.20210846.
October 2021
  1. S. Wu, L.A. Galan, M. Roux, F. Riobe, B. Le Guennic, Y. Guyot, T. Le Bahers, L. Micouin, O. Maury, E. Benedetti “Tuning the excited state properties of [2.2]paracyclophane-based antennas to ensure efficient sensitization of lanthanide ions or singlet oxygen generation” Inorg. Chem. 2021, 60, 16194−16203. DOI: https://doi.org/10.1021/acs.inorgchem.1c01986.
  2. F. Bouchet, H. Atze,  M. Arthur, M. Etheve-Quelquejeu, L. Iannazzo “Traceless Staudinger ligation to introduce chemical diversity on β-lactamase inhibitors of second generation” Org. Lett., 2021, just accepted. 
September 2021
​A. Corio, C. Gravier-Pelletier, P. Busca “Regioselective Functionalization of Quinolines through C-H Activation: A Comprehensive Review.” Molecules 2021, 26(18), 5467. DOI: https://doi.org/10.3390/molecules26185467
August 2021
  1. ​J. Haubrich, J. Font, R. B. Quast, A. Goupil-Lamy, P. Scholler, D. Nevoltris, F.Acher, P. Chames, P. Rondard, L. Prezeau, J.-P. Pin “A nanobody activating metabotropic glutamate receptor 4 discriminates between homo and heterodimers.” Proc. Natl. Acad. Sci. U S A 2021,  118 (33) e2105848118. DOI: https://doi.org/10.1073/pnas.2105848118
  2. E. Brunetti, L. Marcelis, F. E. Zhurkin, M. Luhmer, I. Jabin, O. Reinaud, K. Bartik “A Water Molecule Triggers Guest Exchange at a Mono-zinc Centre Confined in a Biomimetic Calixarene Pocket: a Model for Understanding Ligand Stability in Zn Proteins” Chem. Eur. J. 2021, 27, 13730-13738 DOI:  https://doi.org/10.1002/chem.202102184.
June 2021
  1. S. Felder, S. Wu, J. Brom, L. Micouin, E. Benedetti “Enantiopure planar chiral [2.2]paracyclophanes: Synthesis and applications in asymmetric organocatalysis”  Chirality, 2021, 33, 506-527 DOI: https://doi.org/10.1002/chir.23335
April 2021
  1. B. Colasson, T. Devic, J. Gaubicher, C. Martineau-Corcos, P. Poizot, Vincent Sarou-Kanian “Dual Electroactivity in a Covalent-Organic Network with Mechanically Interlocked Pillar[5]arenes”
    Chem. Eur. J., 2021, Accepted. DOI: http://dx.doi.org/10.1002/chem.202100558.
  2. S. Saidjalolov, E. Braud, Z. Edoo, L. Iannazzo, F. Rusconi, M. Riomet, A. Sallustrau, F. Taran, M. Arthur, M. Fonvielle, M. Etheve‐Quelquejeu “Click and Release Chemistry for Activity‐Based Purification of β‐Lactam Targets”
    Chem. Eur. J., 2021, Accepted. DOI: https://doi.org/10.1002/chem.202100653
Mars 2021
S. Felder, L. Micouin, E. Benedetti “Para‐functionalization of N‐substituted 4‐amino[2.2]paracyclophanes by regioselective formylation” Eur. J. Org. Chem., 2021, 4015-4018. DOI: https://doi.org/10.1002/ejoc.202100288
January 2021
  1. Rietmeyer, N. Fix-boulier, C. Le Fournis, L. Iannazzo, C. Kitoun, D. Patin, D. Mengin-lecreulx, M. Etheve-Quelquejeu, M. Arthur, M. Fonvielle “Partition of tRNAGly isoacceptors between protein and cell-wall peptidoglycan synthesis in Staphylococcus aureus”, Nucleic Acid Res. 2021, Accepted. DOI: http://doi.org/10.1093/nar/gkaa1242
  2. S. Saidjalolov, Z. Edoo, M. Fonvielle, L. Mayer, L. Iannazzo, M. Arthur, M. Etheve-Quelquejeu, E. Braud “Synthesis of carbapenems containing peptidoglycan-mimetics and inhibition of the cross-linking activity of a transpeptidase of the L,D specificity” Chem. Eur. J., 2021, Accepted. DOI: http://doi.org/10.1002/chem.202004831
  3. de Sa Nogueira D, Bourdy R, Filliol D, Quessada C, McCort-Tranchepain I, Acher F, Zwiller J, Romieu P, Befort K. “LSP2-9166, an orthosteric mGlu4 and mGlu7 receptor agonist, reduces cocaine self-administration under a progressive ratio schedule in rats” Neurosci Lett. 2020, 135603 https://doi.org/10.1016/j.neulet.2020.135603
  4. K. Abbas, N. Babić, F. Peyrot. “Detection of superoxide radical in adherent living cells by electron paramagnetic resonance (EPR) spectroscopy using cyclic nitrones”. Methods Mol. Biol. 2021, 2202, 149-163. DOI: https://doi.org/10.1007/978-1-0716-0896-8_13
November 2020
  1. B. Li, Y. Li, C. Tomkiewicz-Raulet, P. Dao, D. Lietha, E. Yen-Pon, Z. Du, X. Coumoul, C. Garbay, M. Etheve-Quelquejeu, H. Chen “Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma” J. Med. Chem. 2020, 63, 12707-12724. DOI: 10.1021/acs.jmedchem.0c01059
  2. M. Bosco, S.-J. Paik, P. Busca, S. E. H. Moore, C. Gravier-Pelletier “Synthetic Route to Glycosyl β-1C-(phosphino)-phosphonates as Unprecedented Stable Glycosyl Diphosphate Analogs and Their Preliminary Biological Evaluation” Molecules 2020, 25, 4969. DOI: 10.3390/molecules25214969
  3. C. Fleurisson, E. Benedetti, L. Micouin Cyclic cis-1,3-Diamines Derived from Bicyclic Hydrazines: Synthesis and Applications Synlett 2021, 31, 858-874. DOI: 10.1055/s-0040-1707324
  4. X. Chen, P. Coric, V. Larue, S. Turcaud, X. Wang, S. Nonin-Lecomte, S. Bouaziz “The HIV-1 maturation inhibitor, EP39, interferes with the dynamic helix-coil equilibrium of the CA-SP1 junction of Gag” Eur. J. Med. Chem., 2020, 204, 112634 DOI: https://doi.org/10.1016/j.ejmech.2020.112634
October 2020
  1. C. Kitoun, M. Fonvielle, N. Sakkas, M. Lefresne, F. Djago, Q. Blancart Remaury, P. Poinot, M. Arthur, M. Etheve-Quelquejeu, L. Iannazzo. “Phosphine-Mediated Bioconjugation of the 3′-end of RNA” Org. Lett., 2020, Just Acccepted.   https://doi.org/10.1021/acs.orglett.0c02982
  2. C. Aubry, P. Clerici, C. Gerbaud, L. Micouin, J.-L. Pernodet, S. Lautru, Revised structure of Anthelvencine A and characterization of the Anthelvencin Biosynthetic gene cluster.  ACS Chem Biol. 2020, 15, 945-951. https://doi.org/10.1021/acschembio.9b00960
  3. T. Zhang, L. Le Corre, O. Reinaud, B. Colasson “A Promising Approach for Controlling the 2nd Coordination Sphere of Biomimetic Metal Complexes: Encapsulation in a Dynamic Hydrogen-Bonded Capsule” Chem. Eur. J. 2020 in press. https://doi.org/10.1002/chem.202004370.
  4. J. K. Aw, K. C. Boellaard, T. K. Tan, J. Yap, Y.P. Loh, B. Colasson, È. Blanc, Y. Lam, F. M. Fung “Interacting with Three-Dimensional Molecular Structures Using an Augmented Reality Mobile App” J. Chem. Ed. 2020, 97, 3877-3881. https://doi.org/10.1021/acs.jchemed.0c00387
July 2020
1) Dubois L, Pietrancosta N, Cabaye A, Fanget I, Debacker C, Gilormini PA, Dansette PM, Dairou J, Biot C, Froissart R, Goupil-Lamy A, Bertrand HO, Acher FC, McCort-Tranchepain I, Gasnier B, Anne C. “Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.” J. Med. Chem. 2020  Online ahead of print.  https://doi.org/10.1021/acs.jmedchem.9b02119.  PMID: 32608236

2) H.Liu, Ping Yi, W. Zhao, Y. Wu, F. Acher, J.-P. Pin, J. Liu and P. Rondard “Illuminating the allosteric modulation of the calcium-sensing receptor” Proc Natl Acad Sci U S A 2020, 117, 21711-21722. https://doi.org/10.1073/pnas.1922231117

3) C. Atdjian, D. Coelho, L. Iannazzo , M. Ethève-Quelquejeu, E. Braud “Synthesis of Triazole-Linked SAM-Adenosine Conjugates: Functionalization of Adenosine at N-1 or N-6 Position without Protecting Groups” Molecules 2020, 25, 3241; https://doi.org/10.3390/molecules25143241

June 2020

1) N. Babić, M. Orio, F. Peyrot. “Unexpected rapid aerobic transformation of 2,2,6,6-tetraethyl-4-oxo(piperidin-1-yloxyl) radical by cytochrome P450 in the presence of NADPH: Evidence against a simple reduction of the nitroxide moiety to the hydroxylamine”. Free Radic. Biol. Med. 2020, 156, 144-156. DOI: https://doi.org/10.1016/j.freeradbiomed.2020.05.021

 

Mai 2020
(1) Y. Luo, Y. Xiao, D. Onidas, L. Iannazzo, M. Ethève-Quelquejeu, A. Lamouri, N. Félidj, S. Mahouche-Chergui, T. Brulé, N. Gagey-Eilstein, F. Gazeau, C. Mangeney “Raman reporters derived from aryl diazonium salts for SERS encoded-nanoparticles”.  Chem. Commun., 2020, Advance Article https://doi.org/10.1039/D0CC02842H
April 2020
(1) Flavie Bouchet, Heiner Atze, Matthieu Fonvielle, Zainab Edoo, Michel Arthur, Mélanie Ethève-Quelquejeu, Laura Iannazzo “Diazabicyclooctane functionalization for inhibition of β-lactamases from enterobacteria”. Journal of Medicinal Chemistry, Just Accepted, https://doi.org/10.1021/acs.jmedchem.9b02125
March 2020
(1) A. Mikou, A. Cabayé, A. Goupil, H.-O. Bertrand, J.-P. Mothet, F. Acher “Asc-1 Transporter (SLC7A10): Homology models and molecular dynamics insights into the first steps of the transport mechanism.” Sci.Rep. DOI: doi.org/10.1038/s41598-020-60617-y

(2) Poirel O, Mamer LE, Herman MA, Arnulf-Kempcke M, Kervern M, Potier B, Miot S, Wang J, Favre-Besse FC, Brabet I, Laras Y, Bertrand HO, Acher F, Pin JP, Puel JL, Giros B, Epelbaum J, Rosenmund C, Dutar P, Daumas S, El Mestikawy S, Pietrancosta N. “LSP5-2157 a new inhibitor of vesicular glutamate transporters.” Neuropharmacology. 2020 164 107902. doi: 10.1016/j.neuropharm.2019.107902.

January 2020
B. Colasson, A. Credi, B. Ventura “Photoinduced electron transfer involving a naphthalimide chromophore in switchable and flexible [2]rotaxanes“ Chem. Eur. J., 2020, 26, 534-542. doi: 10.1002/chem.201904155.
December 2019
  1. H. Habrian, J. Levitz, V. Vyklicky, Z. Fu, A.Hoagland, I. McCort-Tranchepain, F. Acher, E. Y. Isacoff “Conformational pathway provides unique sensitivity to a synaptic mGluR” Nature Commun. 2019, 10, 5572 doi:10.1038/s41467-019-13407-8
  2. Abi Fayssal, A. Giungi, F. Berhal, G. Prestat “Iron-Catalyzed Intra-intermolecular Aminoazidation of Alkenes” Org. Process Res. Dev., 10.1021/acs.oprd.9b00400
November 2019
Hayek, N. Pietrancosta, A. A. Hovhannisyan, R. Alves de Sousa N. Bekaddour, L. Ermellino, E. Tramontano, S. Arnould, C. Sardet, J. Dairou, O. Diaz, V. Lotteau, S. Nisole, G. Melikyan, J.-H. Herbeuval, P.- O. Vidalain. “Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition” Eur. J. Med. Chem. DOI: 10.1016/j.ejmech.2019.111855
October 2019
Zahim, D. Ajami, P. Laurent, H. Valkenier, O. Reinaud, M. Luhmer, I. Jabin ” Synthesis and Binding Properties of a Tren-Capped Hexahomotrioxacalix[3]arene” ChemPhysChem 10.1002/cphc.201900951
September 2019

N. Babić, F. Peyrot. “New synthetic route to 2,2,6,6-tetraethylpiperidin-4-one: A key-intermediate towards tetraethyl nitroxides”. Tet. Lett. 2019, 60(44), 151207. DOI: https://doi.org/10.1016/j.tetlet.2019.151207

February 2019

N. Babić, F. Peyrot. “Molecular Probes for Evaluation of Oxidative Stress by In Vivo EPR Spectroscopy and Imaging: State-of-the-Art and Limitations”. Magnetochemistry 2019, I(1), 13. DOI: https://doi.org/10.3390/magnetochemistry5010013